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Slater, Rachael, Tharmaratnam, Kukatharmini, Belnour, Salma, Auth, Marcus Karl-Heinz, Muhammed, Rafeeq, Spray, Christine, Wang, Duolao 
ORCID: https://orcid.org/0000-0003-2788-2464, De Lacy Costello, Ben, Garcia-Finana, Marta, Allen, Stephen ORCID: https://orcid.org/0000-0001-6675-249X and Probert, Chris
(2024)
'Gas Chromatography–Sensor System Aids Diagnosis of Inflammatory Bowel Disease, and Separates Crohn’s from Ulcerative Colitis, in Children'. Sensors, Vol 24, Issue 15, p. 5079.
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sensors-24-05079-v2.pdf - Published Version Available under License Creative Commons Attribution. Download (1MB) | Preview |
Abstract
The diagnosis of inflammatory bowel disease (IBD) in children and the need to distinguish between subtypes (Crohn’s disease (CD) and ulcerative colitis (UC)) requires lengthy investigative and invasive procedures. Non-invasive, rapid, and cost-effective tests to support these diagnoses are needed. Faecal volatile organic compounds (VOCs) are distinctive in IBD. VOC profiles can be rapidly determined using a gas chromatography–sensor device (OdoReader©). In an inception-cohort of children presenting with suspected IBD, we directly compared the diagnostic fidelity of faecal calprotectin (FCP, a non-specific protein marker of intestinal inflammation) with OdoReader© VOC profiles of children subsequently diagnosed with IBD with matched controls diagnosed with other gastrointestinal conditions. The OdoReader© was 82% (95% confidence interval 75–89%) sensitive and 71% (61–80%) specific but did not outperform FCP (sensitivity 93% (77–99%) and specificity 86% (67–96%); 250 µg/g FCP cut off) in the diagnosis of IBD from other gastrointestinal conditions when validated in a separate sample from the same cohort. However, unlike FCP and better than other similar technologies, the OdoReader© could distinguish paediatric CD from UC (up to 88% (82–93%) sensitivity and 80% (71–89%) specificity in the validation set) and justifies further validation in larger studies. A non-invasive test based on VOCs could help streamline and limit invasive investigations in children.
| Item Type: | Article | ||||
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| Subjects: | QY Clinical Pathology > QY 25 Laboratory techniques and procedure WI Digestive System > WI 140 Diseases (General) WI Digestive System > WI 20 Research (General) WS Pediatrics > Diseases of Children and Adolescents > By System > WS 310 Digestive system |
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| Faculty: Department: | Clinical Sciences & International Health > Clinical Sciences Department | ||||
| Digital Object Identifer (DOI): | https://doi.org/10.3390/s24155079 | ||||
| Depositing User: | Jane Rawlinson | ||||
| Date Deposited: | 08 Aug 2024 16:08 | ||||
| Last Modified: | 08 Aug 2024 16:15 | ||||
| URI: | https://archive.lstmed.ac.uk/id/eprint/25088 |
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