Progress and Challenges in the Field of Snakebite Envenoming Therapeutics

Gutiérrez, José María, Casewell, Nicholas ORCID: https://orcid.org/0000-0002-8035-4719 and Laustsen, Andreas H. (2024) 'Progress and Challenges in the Field of Snakebite Envenoming Therapeutics'. Annual Review of Pharmacology and Toxicology, Vol 65. (In Press)

Text Casewell, Gutiérrez, Laustsen v20AHL.pdf - Accepted Version Restricted to Repository staff only until 1 August 2025. Download (590kB)

Abstract

Snakebite envenoming kills and maims hundreds of thousands of people every year, especially in the rural settings of tropical regions. Envenomings are still treated with animal-derived antivenoms, which have prevented many lives from being lost but which are also medicines in need of innovation. Strides are being made to improve envenoming therapies, with promising efforts made toward optimizing manufacturing and quality aspects of existing antivenoms, accelerating research and development of recombinant antivenoms based on monoclonal antibodies, and repurposing of small-molecule inhibitors that block key toxins. Here, we review the most recent advances in these fields and discuss therapeutic opportunities and limitations for different snakebite treatment modalities. Finally, we discuss challenges related to preclinical and clinical evaluation, regulatory pathways, large-scale manufacture, and distribution and access that need to be addressed to fulfill the goals of the World Health Organization's global strategy to prevent and control snakebite envenoming.

Item Type:	Article
Subjects:	QV Pharmacology > Toxicology > General Toxicology > QV 601 Antidotes and other therapeutic measures QW Microbiology and Immunology > Antigens and Antibodies. Toxins and Antitoxins > QW 630 Toxins. Antitoxins WD Disorders of Systemic, Metabolic or Environmental Origin, etc > Animal Poisons > WD 410 Reptiles
Faculty: Department:	Biological Sciences > Department of Tropical Disease Biology
Digital Object Identifer (DOI):	https://doi.org/10.1146/annurev-pharmtox-022024-033544
SWORD Depositor:	JISC Pubrouter
Depositing User:	JISC Pubrouter
Date Deposited:	15 Oct 2024 10:04
Last Modified:	15 Nov 2024 16:28
URI:	https://archive.lstmed.ac.uk/id/eprint/25124

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