Guidance for conducting and evaluating serological surveys to assess interruption of yaws transmission in the context of an eradication target

Mitjà, Oriol, Gass, Katherine, Marks, Michael, Cooper, Philip, Diggle, Peter, Waller, Lance, Agana-Nsiire, Patrick, Dofitas, Belen Lardizabal, Dyson, Louise, Jacobson, Julie, Kaldor, John, Kim, Sung Hye, Vaz Nery, Susana, Revankar, Chandrakant, Sopoh, Ghislain, Solomon, Anthony W., Dagne, Daniel Argaw, Pathak, Priya, Yajima, Aya, Lin, Zaw, Barogui, Mahoutondji Yves Thierry, Scholte, Ronaldo Carvalho, Sanikullah, Kazim Hizbullah, Drakeley, Chris, Stresman, Gillian, Gyapong, John and Asiedu, Kingsley Bampoe (2025) Guidance for conducting and evaluating serological surveys to assess interruption of yaws transmission in the context of an eradication target. Neglected Tropical Diseases, Public Library of Science. 19.

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Abstract

This document provides a summary of guidance developed for national programmes on conducting serosurveys to assess yaws transmission status, with the objective of confirming yaws seroprevalence below 1% at each of three serosurveys over a period of 3–10 years after reporting the last case of active yaws in a region. It proposes active testing of children aged 1–5 years through population-based surveys and includes recommendations on survey design, sample size determination, sampling of primary sampling units (PSUs) within an evaluation unit, sampling of households within PSUs, integration with existing public health surveys, and follow-up protocols for positive results. Geospatial analysis and sustained surveillance are recommended for accurate assessment of whether transmission interruption has been achieved.

Item Type:	Other
Subjects:	QW Microbiology and Immunology > Antigens and Antibodies. Toxins and Antitoxins > QW 570 Serology. WC Communicable Diseases > Infection. Bacterial Infections > Other Bacterial Infections. Zoonotic Bacterial Infections > WC 425 Yaws
Faculty: Department:	Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI):	https://doi.org/10.1371/journal.pntd.0012899
SWORD Depositor:	JISC Pubrouter
Depositing User:	JISC Pubrouter
Date Deposited:	01 May 2025 13:57
Last Modified:	01 May 2025 13:57
URI:	https://archive.lstmed.ac.uk/id/eprint/26601

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