Smith, J. B., Theakston, R.David G., Coelho, A. L. J., Barja-Fidalgo, C., Calvete, J. J. and Marcinkiewicz, C. (2002) 'Characterization of a monomeric disintegrin, ocellatusin, present in the venom of the Nigerian carpet viper, Echis ocellatus'. FEBS Letters, Vol 512, Issue 1-3, pp. 111-115.
Full text not available from this repository.Abstract
Ocellatusin is a new RGD-containing short monomeric disintegrin. It is a better inhibitor of alpha(5)beta(1) integrin and a more potent inducer of the expression of a ligand-induced binding site epitope on beta(1) integrin subunit than echistatin. In further contrast to echistatin, ocellatusin has a direct chemotactic stimulus on human neutrophils in vitro. The distinct effects of these two close evolutionarily related disintegrins might be explained by the presence of methionine-22 and histidine-29 in the RGD loop of ocellatusin, which are arginine and aspartic acid, respectively, in echistatin. These mutations may modulate the conformation and/or recognition properties of the integrin-binding loop of ocellatusin.
Item Type: | Article |
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Subjects: | QU Biochemistry > Cells and Genetics > QU 350 Cellular structures QU Biochemistry > Proteins. Amino Acids. Peptides > QU 58.5 DNA. WD Disorders of Systemic, Metabolic or Environmental Origin, etc > Animal Poisons > WD 410 Reptiles |
Faculty: Department: | Groups (2002 - 2012) > Molecular & Biochemical Parasitology Group |
Digital Object Identifer (DOI): | https://doi.org/10.1016/s0014-5793(02)02233-0 |
Depositing User: | Lynn Roberts-Maloney |
Date Deposited: | 13 Feb 2014 11:31 |
Last Modified: | 06 Feb 2018 13:05 |
URI: | https://archive.lstmed.ac.uk/id/eprint/2985 |
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