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La Pensée, Louise, Sabbani, Sunil, Sharma, Raman, Bhamra, Inder, Shore, Emma, Chadwick, Amy E, Berry, Neil G, Firman, James, Araujo, Nuna C, Cabral, Lília, Cristiano, Maria L S, Bateman, Cerys, Janneh, Omar, Gavrila, Adelina, Wu, Yi Hang, Hussain, Afthab, Ward, Stephen 
ORCID: https://orcid.org/0000-0003-2331-3192, Stocks, Paul A., Cosstick, Rick and O'Neill, Paul M
(2013)
'Artemisinin-polypyrrole conjugates: synthesis, DNA binding studies and preliminary antiproliferative evaluation.'. ChemMedChem, Vol 8, Issue 5, pp. 709-718.
Abstract
Greater than the sum of its parts: Artemisinins are currently in phase I-II clinical trials against breast, colorectal and non-small-cell lung cancers. In an attempt to offer increased specificity, a series of hybrid artemisinin-polypyrrole minor groove binder conjugates are described. DNA binding/modelling studies and preliminary biological evaluation give insights into their mechanism of action and the potential of this strategy.
| Item Type: | Article |
|---|---|
| Subjects: | QU Biochemistry > Cells and Genetics > QU 350 Cellular structures QU Biochemistry > Genetics > QU 550 Genetic techniques. PCR. Chromosome mapping QU Biochemistry > Proteins. Amino Acids. Peptides > QU 58.5 DNA. QW Microbiology and Immunology > Immunity by Type > QW 568 Cellular immunity. Immunologic cytotoxicity. Immunocompetence. Immunologic factors (General) |
| Faculty: Department: | Biological Sciences > Department of Tropical Disease Biology |
| Digital Object Identifer (DOI): | https://doi.org/10.1002/cmdc.201200536 |
| Depositing User: | Mary Creegan |
| Date Deposited: | 15 Aug 2014 08:35 |
| Last Modified: | 06 Feb 2018 13:07 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/3843 |
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