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Pyomyositis in the upper Negro river basin, Brazilian Amazonia

Borges, Álvaro H.D., Faragher, Brian and Lalloo, David ORCID: (2012) 'Pyomyositis in the upper Negro river basin, Brazilian Amazonia'. Transactions of the Royal Society of Tropical Medicine and Hygiene, Vol 106, Issue 9, pp. 532-537.

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Pyomyositis remains poorly documented in tropical Latin America. We therefore performed a retrospective review of cases admitted to a hospital in the upper Negro river basin during 2002–2006. Seasonality was assessed by the cosinor model and independent predictors of outcome were identified by logistic regression. Determinants of time-to-fever resolution were analysed using Cox regression. No seasonal trend was observed (p=0.284) among 82 hospitalised patients. The disease predominated in young males and the most commonly affected part of the body was the lower limb (68 [63.5%] out of 107 lesions). Staphylococcus aureus was the only identified infecting organism (18 of 20 culture results, 90%). Complications occurred in 17 patients (20.7%) and the case fatality rate was 2.4%. Children were more likely to present with eosinophilia than adults (OR= 4.20, 95% CI 1.08–16.32, p=0.048), but no other significant differences regarding clinical presentation and outcomes were observed. The time-to-fever resolution was the only independent determinant of poor outcome (OR=1.52, 95% CI 1.22–1.92, p<0.001) and was significantly longer in patients treated with combined antibiotic therapy than in those treated with single antibiotics (HR=0.523, 95% CI 0.296–0.926, p=0.026). Further studies to determine the best antibiotic therapy modality for the treatment of pyomyositis are required.

Item Type: Article
Subjects: WA Public Health > WA 105 Epidemiology
WC Communicable Diseases > Infection. Bacterial Infections > Bacterial Infections > WC 250 Staphylococcal infections
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 680 Tropical diseases (General)
Faculty: Department: Groups (2002 - 2012) > Clinical Group
Digital Object Identifer (DOI):
Depositing User: Lynn Roberts-Maloney
Date Deposited: 12 Dec 2014 12:23
Last Modified: 06 Feb 2018 13:08


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