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Borges, Álvaro H.D., Faragher, Brian and Lalloo, David 
ORCID: https://orcid.org/0000-0001-7680-2200
(2012)
'Pyomyositis in the upper Negro river basin, Brazilian Amazonia'. Transactions of the Royal Society of Tropical Medicine and Hygiene, Vol 106, Issue 9, pp. 532-537.
Abstract
Pyomyositis remains poorly documented in tropical Latin America. We therefore performed a retrospective review of cases admitted to a hospital in the upper Negro river basin during 2002–2006. Seasonality was assessed by the cosinor model and independent predictors of outcome were identified by logistic regression. Determinants of time-to-fever resolution were analysed using Cox regression. No seasonal trend was observed (p=0.284) among 82 hospitalised patients. The disease predominated in young males and the most commonly affected part of the body was the lower limb (68 [63.5%] out of 107 lesions). Staphylococcus aureus was the only identified infecting organism (18 of 20 culture results, 90%). Complications occurred in 17 patients (20.7%) and the case fatality rate was 2.4%. Children were more likely to present with eosinophilia than adults (OR= 4.20, 95% CI 1.08–16.32, p=0.048), but no other significant differences regarding clinical presentation and outcomes were observed. The time-to-fever resolution was the only independent determinant of poor outcome (OR=1.52, 95% CI 1.22–1.92, p<0.001) and was significantly longer in patients treated with combined antibiotic therapy than in those treated with single antibiotics (HR=0.523, 95% CI 0.296–0.926, p=0.026). Further studies to determine the best antibiotic therapy modality for the treatment of pyomyositis are required.
| Item Type: | Article |
|---|---|
| Subjects: | WA Public Health > WA 105 Epidemiology WC Communicable Diseases > Infection. Bacterial Infections > Bacterial Infections > WC 250 Staphylococcal infections WC Communicable Diseases > Tropical and Parasitic Diseases > WC 680 Tropical diseases (General) |
| Faculty: Department: | Groups (2002 - 2012) > Clinical Group |
| Digital Object Identifer (DOI): | https://doi.org/10.1016/j.trstmh.2012.06.008 |
| Depositing User: | Lynn Roberts-Maloney |
| Date Deposited: | 12 Dec 2014 12:23 |
| Last Modified: | 06 Feb 2018 13:08 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/4653 |
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