Synthesis and evaluation of the antimalarial, anticancer, and caspase 3 activities of tetraoxane dimers

Amewu, Richard K., Chadwick, James, Hussain, Afthab, Panda, Somnath, Rinki, Rinki, Janneh, Omar, Ward, Stephen ORCID: https://orcid.org/0000-0003-2331-3192, Miguel, Candel, Burrell-Saward, Hollie, Vivas, Livia and O’Neill, Paul M. (2013) 'Synthesis and evaluation of the antimalarial, anticancer, and caspase 3 activities of tetraoxane dimers'. Bioorganic and Medicinal Chemistry, Vol 21, Issue 23, pp. 7392-7397.

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Abstract

The synthesis of a range of mono spiro and dispiro 1,2,4,5-tetraoxane dimers is described. Selected molecules were examined in in vitro assays to determine their antimalarial and anticancer potential. Our studies reveal that several molecules possess potent nanomolar antimalarial and single digit micromolar antiproliferative IC50s versus colon (HT29-AK and leukemia (HL60) cell lines.

Item Type:	Article
Subjects:	QU Biochemistry > Cells and Genetics > QU 350 Cellular structures QV Pharmacology > Anti-Inflammatory Agents. Anti-Infective Agents. Antineoplastic Agents > QV 256 Antimalarials QV Pharmacology > Anti-Inflammatory Agents. Anti-Infective Agents. Antineoplastic Agents > QV 269 Antineoplastic agents. Antineoplastic antibiotics
Faculty: Department:	Biological Sciences > Department of Tropical Disease Biology
Digital Object Identifer (DOI):	https://doi.org/10.1016/j.bmc.2013.09.047
Depositing User:	Lynn Roberts-Maloney
Date Deposited:	10 Feb 2015 09:44
Last Modified:	06 Feb 2018 13:08
URI:	https://archive.lstmed.ac.uk/id/eprint/4867

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