Population-Level Antibody Estimates to Novel Influenza A/H7N9

Boni, M. F., Chau, N. V. V., Dong, N., Todd, Stacy, Nhat, N. T. D., de Bruin, E., van Beek, J., Hien, N. T., Simmons, C. P., Farrar, J. and Koopmans, M. (2013) 'Population-Level Antibody Estimates to Novel Influenza A/H7N9'. Journal of Infectious Disease, Vol 208, Issue 4, pp. 554-558.

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Abstract

There are no contemporary data available describing human immunity to novel influenza A/H7N9. Using 1723 prospectively collected serum samples in southern Vietnam, we tested for antibodies to 5 avian influenza virus antigens, using a protein microarray. General-population antibody titers against subtype H7 virus are higher than antibody titers against subtype H5 and lower than titers against H9. The highest titers were observed for human influenza virus subtypes. Titers to avian influenza virus antigens increased with age and with geometric mean antibody titer to human influenza virus antigens. There were no titer differences between the urban and the rural location in our study.

Item Type:	Article
Subjects:	QW Microbiology and Immunology > Antigens and Antibodies. Toxins and Antitoxins > QW 570 Serology. QW Microbiology and Immunology > Antigens and Antibodies. Toxins and Antitoxins > QW 575 Antibodies WA Public Health > WA 105 Epidemiology WC Communicable Diseases > Virus Diseases > Viral Respiratory Tract Infections. Respirovirus Infections > WC 515 Human influenza
Faculty: Department:	Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI):	https://doi.org/10.1093/infdis/jit224
Depositing User:	Lynn Roberts-Maloney
Date Deposited:	13 Feb 2015 11:16
Last Modified:	07 Dec 2018 09:48
URI:	https://archive.lstmed.ac.uk/id/eprint/4901

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