Snake antivenom for snake venom induced consumption coagulopathy

Maduwage, Kalana, Buckley, Nick A., Janaka de Silva, H., Lalloo, David ORCID: https://orcid.org/0000-0001-7680-2200 and Isbister, Geoffrey K. (2015) 'Snake antivenom for snake venom induced consumption coagulopathy'. Cochrane Database of Systematic Reviews, Vol 6, CD011428.

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Abstract

Background

Snake venom induced consumption coagulopathy is a major systemic effect of envenoming. Observational studies suggest that antivenom improves outcomes for venom induced consumption coagulopathy in some snakebites and not others. However, the effectiveness of snake antivenom in all cases of venom induced consumption coagulopathy is controversial.

Objectives

To assess the effect of snake antivenom as a treatment for venom induced consumption coagulopathy in people with snake bite.

Search methods

The search was done on 30 January 2015. We searched the Cochrane Injuries Group's Specialised Register, the Cochrane Central Register of Controlled Trials (CENTRAL, The Cochrane Library), Ovid MEDLINE(R), Ovid MEDLINE(R) In-Process & Other Non-Indexed Citations, Ovid MEDLINE(R) Daily and Ovid OLDMEDLINE(R), Embase Classic+Embase (OvidSP), three other sources, clinical trials registers, and we also screened reference lists.

Selection criteria

All completed, published or unpublished, randomised, controlled trials with a placebo or no treatment arm, where snake antivenom was administered for venom induced consumption coagulopathy in humans with snake bites.

Data collection and analysis

Two authors reviewed the identified trials and independently applied the selection criteria.

Main results

No studies met the inclusion criteria for this review.

Item Type:	Article
Additional Information:	This review is published as a Cochrane Review in the Cochrane Database of Systematic Reviews 2015, Issue 6, CD011428. Cochrane Reviews are regularly updated as new evidence emerges and in response to comments and criticisms, and the Cochrane Database of Systematic Reviews should be consulted for the most recent version of the Review
Subjects:	QV Pharmacology > Toxicology > General Toxicology > QV 601 Antidotes and other therapeutic measures WD Disorders of Systemic, Metabolic or Environmental Origin, etc > Animal Poisons > WD 410 Reptiles
Faculty: Department:	Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI):	https://doi.org/10.1002/14651858.CD011428.pub2
Depositing User:	Annmarie Hand
Date Deposited:	24 Jul 2015 14:15
Last Modified:	06 Feb 2018 13:10
URI:	https://archive.lstmed.ac.uk/id/eprint/5251

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