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Wang, Y. T., Mohammed, S. D., Farmer, A. D., Wang, Duolao 
ORCID: https://orcid.org/0000-0003-2788-2464, Zarate, N., Hobson, A. R., Hellström, P. M., Semler, J. R., Kuo, B., Rao, S. S., Hasler, W. L., Camilleri, M. and Scott, S. M.
(2015)
'Regional gastrointestinal transit and pH studied in 215 healthy volunteers using the wireless motility capsule: influence of age, gender, study country and testing protocol'. Alimentary Pharmacology & Therapeutics, Vol 42, Issue 6, pp. 761-772.
Abstract
Background
The wireless motility capsule (WMC) offers the ability to investigate luminal gastrointestinal (GI) physiology in a minimally invasive manner.
Aim
To investigate the effect of testing protocol, gender, age and study country on regional GI transit times and associated pH values using the WMC.
Methods
Regional GI transit times and pH values were determined in 215 healthy volunteers from USA and Sweden studied using the WMC over a 6.5-year period. The effects of test protocol, gender, age and study country were examined.
Results
For GI transit times, testing protocol was associated with differences in gastric emptying time (GET; shorter with protocol 2 (motility capsule ingested immediately after meal) vs. protocol 1 (motility capsule immediately before): median difference: 52 min, P = 0.0063) and colonic transit time (CTT; longer with protocol 2: median 140 min, P = 0.0189), but had no overall effect on whole gut transit time. Females had longer GET (by median 17 min, P = 0.0307), and also longer CTT by (104 min, P = 0.0285) and whole gut transit time by (263 min, P = 0.0077). Increasing age was associated with shorter small bowel transit time (P = 0.002), and study country also influenced small bowel and CTTs. Whole gut and CTTs showed clustering of data at values separated by 24 h, suggesting that describing these measures as continuous variables is invalid. Testing protocol, gender and study country also significantly influenced pH values.
Conclusions
Regional GI transit times and pH values, delineated using the wireless motility capsule (WMC), vary based on testing protocol, gender, age and country. Standardisation of testing is crucial for cross-referencing in clinical practice and future research.
| Item Type: | Article |
|---|---|
| Subjects: | QY Clinical Pathology > QY 25 Laboratory techniques and procedure WB Practice of Medicine > WB 25 Technique of research in internal medicine WI Digestive System > WI 20 Research (General) |
| Faculty: Department: | Clinical Sciences & International Health > Clinical Sciences Department |
| Digital Object Identifer (DOI): | https://doi.org/10.1111/apt.13329 |
| Depositing User: | Lynn Roberts-Maloney |
| Date Deposited: | 13 Oct 2015 08:36 |
| Last Modified: | 06 Sep 2019 15:26 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/5356 |
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