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The stratified win ratio

Dong, Gaohong, Qiu, Junshan, Wang, Duolao ORCID: and Vandemeulebroecke, Marc (2018) 'The stratified win ratio'. Journal of Biopharmaceutical Statistics, Vol 28, Issue 4, pp. 778-796.

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The win ratio was first proposed in 2012 by Pocock and his colleagues to analyze a composite endpoint while considering the clinical importance order and the relative timing of its components. It has attracted considerable attention since then, in applications as well as methodology. It is not uncommon that some clinical trials require a stratified analysis. In this article, we propose a stratified win ratio statistic in a similar way as the Mantel-Haenszel stratified odds ratio, derive a general form of its variance estimator with a plug-in of existing or potentially new variance/covariance estimators of the number of wins for the two treatment groups, and assess its statistical performance using simulation studies. Our simulations show that our proposed Mantel-Haenszel-type stratified win ratio performs similarly to the Mantel-Haenszel stratified odds ratio for the simplified situation when the win ratio reduces to the odds ratio, and our proposed stratified win ratio is preferred compared to the inverse-variance weighted win ratio and unweighted win ratio particularly when the data are sparse. We also formulate a homogeneity test following Cochran's approach that assesses whether the stratum-specific win ratios are homogeneous across strata, as this method is used frequently in meta-analyses and a better test for the win ratio homogeneity is not available yet.

Item Type: Article
Subjects: W General Medicine. Health Professions > W 1-28 Reference works
W General Medicine. Health Professions > W 26.5 Informatics. Health informatics
QV Pharmacology > QV 4 General works
W General Medicine. Health Professions > W 20.5 Biomedical research
Faculty: Department: Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI):
SWORD Depositor: JISC Pubrouter
Depositing User: Stacy Murtagh
Date Deposited: 12 Dec 2017 15:31
Last Modified: 06 Sep 2019 15:27


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