Carbamate resistance in a UK population of the halophilic mosquito Ochlerotatus detritus implicates selection by agricultural usage of insecticide

Brown, Faye, Logan, Rhiannon ORCID: https://orcid.org/0000-0002-4323-3213 and Wilding, Craig Stephen (2019) 'Carbamate resistance in a UK population of the halophilic mosquito Ochlerotatus detritus implicates selection by agricultural usage of insecticide'. International Journal of Pest Management, Vol 65, Issue 4, pp. 284-292.

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Abstract

The salt marsh mosquito Ochlerotatus detritus Haliday, 1833 (Diptera: Culicidae) is locally abundant in some areas of the UK, can be a pernicious summer nuisance biter and is one of eleven British mosquitoes considered as a potential bridge vector of West Nile Virus. WHO
bioassays of insecticide susceptibility were performed on O. detritus from Parkgate Marshes, Little Neston, Wirral, UK using three Insecticides, the pyrethroid permethrin, the carbamate bendiocarb and the organophosphate fenitrothion. O. detritus were fully susceptible to permethrin and fenitrothion but exhibited strong resistance to bendiocarb (66% of females alive following 1–hr exposure; LT50 of 116 minutes). Sequencing of the known resistance-causing mutations in the acetylcholinesterase target site of carbamate/organophosphates, and of
pyrethroids, the voltage-gated sodium channel, revealed no known target-site mutations indicating the carbamate resistance is not target-site mediated. Pre-exposure to the synergist piperonyl butoxide recovered full bendiocarb susceptibility further implicating metabolic
resistance. We show that UK mosquitoes have the potential to develop resistance to insecticides and suggest that the carbamate resistance detected could be a result of exposure to agricultural insecticides.

Item Type:	Article
Subjects:	QX Parasitology > Insects. Other Parasites > QX 510 Mosquitoes WA Public Health > Preventive Medicine > WA 240 Disinfection. Disinfestation. Pesticides (including diseases caused by)
Faculty: Department:	Biological Sciences > Vector Biology Department
Digital Object Identifer (DOI):	https://doi.org/10.1080/09670874.2018.1499985
Depositing User:	Stacy Murtagh
Date Deposited:	19 Nov 2018 10:31
Last Modified:	27 Oct 2019 02:02
URI:	https://archive.lstmed.ac.uk/id/eprint/9638

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