Three phylogenetic groups have driven the recent population expansion of Cryptococcus neoformans.

Ashton, P M, Thanh, L T, Trieu, P H, Van Anh, D, Trinh, N M, Beardsley, J, Kibengo, F, Chierakul, W, Dance, D A B, Rattanavong, S, Davong, V, Hung, L Q, Chau, N V V, Tung, N L N, Chan, A K, Thwaites, G E, Lalloo, David ORCID: https://orcid.org/0000-0001-7680-2200, Anscombe, C, Nhat, L T H, Perfect, J, Dougan, G, Baker, S, Harris, S and Day, J N (2019) 'Three phylogenetic groups have driven the recent population expansion of Cryptococcus neoformans.'. Nature Communications, Vol 10, Issue 1, p. 2035.

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Abstract

Cryptococcus neoformans (C. neoformans var. grubii) is an environmentally acquired pathogen causing 181,000 HIV-associated deaths each year. We sequenced 699 isolates, primarily C. neoformans from HIV-infected patients, from 5 countries in Asia and Africa. The phylogeny of C. neoformans reveals a recent exponential population expansion, consistent with the increase in the number of susceptible hosts. In our study population, this expansion has been driven by three sub-clades of the C. neoformans VNIa lineage; VNIa-4, VNIa-5 and VNIa-93. These three sub-clades account for 91% of clinical isolates sequenced in our study. Combining the genome data with clinical information, we find that the VNIa-93 sub-clade, the most common sub-clade in Uganda and Malawi, was associated with better outcomes than VNIa-4 and VNIa-5, which predominate in Southeast Asia. This study lays the foundation for further work investigating the dominance of VNIa-4, VNIa-5 and VNIa-93 and the association between lineage and clinical phenotype.

Item Type:	Article
Subjects:	QU Biochemistry > Genetics > QU 500 Genetic phenomena QW Microbiology and Immunology > Fungi. Pathogenic Fungi. > QW 180 Pathogenic Fungi QY Clinical Pathology > QY 4 General works WC Communicable Diseases > Mycoses > WC 475 Cryptococcosis. Sporotrichosis
Faculty: Department:	Clinical Sciences & International Health > Clinical Sciences Department Clinical Sciences & International Health > International Public Health Department
Digital Object Identifer (DOI):	https://doi.org/10.1038/s41467-019-10092-5
Depositing User:	Stacy Murtagh
Date Deposited:	08 May 2019 12:36
Last Modified:	08 May 2019 12:36
URI:	https://archive.lstmed.ac.uk/id/eprint/10766

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