LSTM Home > LSTM Research > LSTM Online Archive

Unprecedented reorganization of holocentric chromosomes provides insights into the enigma of lepidopteran chromosome evolution.

Hill, Jason, Rastas, Pasi, Hornett, Emily, Neethiraj, Ramprasad, Clark, Nathan, Morehouse, Nathan, de la Paz Celorio-Mancera, Maria, Cols, Jofre Carnicer, Dircksen, Heinrich, Meslin, Camille, Keehnen, Naomi, Pruisscher, Peter, Sikkink, Kristin, Vives, Maria, Vogel, Heiko, Wiklund, Christer, Woronik, Alyssa, Boggs, Carol L, Nylin, Sören and Wheat, Christopher W (2019) 'Unprecedented reorganization of holocentric chromosomes provides insights into the enigma of lepidopteran chromosome evolution.'. Science Advances, Vol 5, Issue 6, eaau3648.

[img]
Preview
Text
eaau3648.full.pdf - Published Version
Available under License Creative Commons Attribution.

Download (3MB) | Preview

Abstract

Chromosome evolution presents an enigma in the mega-diverse Lepidoptera. Most species exhibit constrained chromosome evolution with nearly identical haploid chromosome counts and chromosome-level gene collinearity among species more than 140 million years divergent. However, a few species possess radically inflated chromosomal counts due to extensive fission and fusion events. To address this enigma of constraint in the face of an exceptional ability to change, we investigated an unprecedented reorganization of the standard lepidopteran chromosome structure in the green-veined white butterfly ( ). We find that gene content in has been extensively rearranged in large collinear blocks, which until now have been masked by a haploid chromosome number close to the lepidopteran average. We observe that ancient chromosome ends have been maintained and collinear blocks are enriched for functionally related genes suggesting both a mechanism and a possible role for selection in determining the boundaries of these genome-wide rearrangements.

Item Type: Article
Subjects: QU Biochemistry > Genetics > QU 500 Genetic phenomena
QU Biochemistry > Genetics > QU 550 Genetic techniques. PCR. Chromosome mapping
QX Parasitology > Insects. Other Parasites > QX 560 Lepidoptera (Moths. Butterflies)
Faculty: Department: Biological Sciences > Vector Biology Department
Digital Object Identifer (DOI): https://doi.org/10.1126/sciadv.aau3648
SWORD Depositor: JISC Pubrouter
Depositing User: JISC Pubrouter
Date Deposited: 01 Jul 2019 08:06
Last Modified: 01 Jul 2019 08:06
URI: https://archive.lstmed.ac.uk/id/eprint/11133

Statistics

View details

Actions (login required)

Edit Item Edit Item