A propensity-matched study of the association between prepregnancy maternal underweight and perinatal outcomes among singletons based on an ART cohort

Qu, Pengfei, Liu, Fangfang, Zhao, Doudou, Wang, Yongbo, Wang, Min, Wang, Linyu, Dang, Shaonong, Wang, Duolao ORCID: https://orcid.org/0000-0003-2788-2464, Shi, Juanzi and Shi, Wenhao (2019) 'A propensity-matched study of the association between prepregnancy maternal underweight and perinatal outcomes among singletons based on an ART cohort'. Reproductive BioMedicine Online, Vol 39, Issue 4, pp. 674-684.

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Abstract

Research question
Is prepregnancy maternal underweight associated with perinatal outcomes of singletons who were conceived by assisted reproductive technology (ART)?
A 10-year (2006-2015) Chinese sample of 6538 women and their singletons who were conceived by ART was used to examine the association between prepregnancy maternal underweight and perinatal outcomes. Propensity scores(PS) for underweight were calculated for each participant using multivariable logistic regression, which was used to match 740 (91.35% of 810) underweight women with 740 normal weight women and then the effects of underweight on birth weight (BW) and gestational age (GA) were assessed by the generalized estimating equation (GEE) model.

Results
After PS matching, the BW was lower (difference=-136.83 g, 95% CI=-184.11 to -89.55 g) in the underweight group than in the normal weight group. The risks of low birth weight (LBW) and small for gestational age (SGA) were increased in the underweight group compared with those in the normal weight group (LBW: RR=1.64, 95% CI=1.01 to 2.67; SGA: RR=1.46, 95% CI=1.06 to 2.02). The risks of fetal macrosomia and being large for gestational age (LGA) were decreased in the underweight group compared with those in the normal weight group (macrosomia: RR=0.39, 95% CI=0.26 to 0.61; LGA: RR=0.36, 95% CI=0.24 to 0.53). The associations between underweight and GA and preterm birth (PTB) were not statistically significant.

Conclusions
Among women undergoing ART, prepregnancy maternal underweight was associated with lower BW, increased LBW and SGA risks and decreased fetal macrosomia and LGA risks in singletons.

Item Type:	Article
Subjects:	WA Public Health > Health Problems of Special Population Groups > WA 310 Maternal welfare WQ Obstetrics > WQ 20 Research (General) WQ Obstetrics > Pregnancy > WQ 200 General works WS Pediatrics > By Age Groups > WS 420 Newborn infants. Neonatology
Faculty: Department:	Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI):	https://doi.org/10.1016/j.rbmo.2019.06.007
Depositing User:	Julie Franco
Date Deposited:	07 Aug 2019 08:24
Last Modified:	22 Jun 2020 01:02
URI:	https://archive.lstmed.ac.uk/id/eprint/11362

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