Molecular surveillance for drug-resistant Plasmodium falciparum malaria in Malawi

Nkhoma, Standwell, Molyneux, Malcolm E and Ward, Stephen ORCID: https://orcid.org/0000-0003-2331-3192 (2007) 'Molecular surveillance for drug-resistant Plasmodium falciparum malaria in Malawi'. Acta Tropica, Vol 102, Issue 2, pp. 138-142.

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Abstract

We assessed the presence of point mutations associated with resistance to chloroquine (CQ) and sulphadoxine-pyrimethamine (SP) in 178 Plasmodium falciparum infections from three geographically distinct sites in Malawi. We confirm that CQ-resistance mutations are now rare in Malawi, being detectable at very low frequencies (2-4%) in infections from two of the three study sites. We also show that over 90% of infections from each of the three study sites carry a set of three dihydrofolate reductase (dhfr) and two dihydropteroate synthase (dhps) mutations strongly associated with SP treatment failure. In this short communication, we present these molecular data and discuss their implications for Malawi's first-line antimalarial treatment policy. (C) 2007 Elsevier B.V. All rights reserved.

Item Type:	Article
Uncontrolled Keywords:	plasmodium falciparum sulphadoxine-pyrimethamine chloroquine antimalarial drug resistance malawi pyrimethamine-sulfadoxine resistance chlorproguanil-dapsone treatment thymidylate synthase gene dihydrofolate-reductase dihydropteroate synthase chloroquine resistance mutations pfcrt parasites efficacy
Subjects:	QV Pharmacology > Anti-Inflammatory Agents. Anti-Infective Agents. Antineoplastic Agents > QV 256 Antimalarials WC Communicable Diseases > Tropical and Parasitic Diseases > WC 765 Prevention and control
Faculty: Department:	Groups (2002 - 2012) > Clinical Group Groups (2002 - 2012) > Molecular & Biochemical Parasitology Group
Digital Object Identifer (DOI):	https://doi.org/10.1016/j.actatropica.2007.04.006
Depositing User:	Ms Julia Martin
Date Deposited:	15 Nov 2010 15:03
Last Modified:	17 Aug 2022 08:56
URI:	https://archive.lstmed.ac.uk/id/eprint/1255

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