Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs

Stocks, Paul A., Bray, Patrick, Barton, V. E., Al-Helal, Mohammed, Jones, M., Araujo, N. C., Gibbons, P., Ward, Stephen ORCID: https://orcid.org/0000-0003-2331-3192, Hughes, Ruth, Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595, Davies, Jill, Amewu, R., Mercer, A. E., Ellis, G. and O'Neill, P. M. (2007) 'Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs'. Angewandte Chemie-International Edition, Vol 46, Issue 33, pp. 6278-6283.

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Item Type:	Article
Uncontrolled Keywords:	antimalarial agents;chelates;confocal imaging;fluorescence;iron; confocal imaging; fluorescence; iron; plasmodium-falciparum; qinghaosu artemisinin; medicinal chemistry heme model derivatives design resistance chelators trioxanes analogs
Subjects:	QV Pharmacology > Anti-Inflammatory Agents. Anti-Infective Agents. Antineoplastic Agents > QV 256 Antimalarials QV Pharmacology > QV 34 Experimental pharmacology (General)
Faculty: Department:	Groups (2002 - 2012) > Molecular & Biochemical Parasitology Group
Digital Object Identifer (DOI):	https://doi.org/10.1002/anie.200604697
Depositing User:	Mary Creegan
Date Deposited:	17 Sep 2010 13:06
Last Modified:	17 Jul 2020 10:58
URI:	https://archive.lstmed.ac.uk/id/eprint/1284

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