Mutated sodium channel genes and elevated monooxygenases are found in pyrethroid resistant populations of Sri Lankan malaria vectors

Karunaratne, S. H. P. P., Hawkes, Nicola J., Perera, M. D. B., Ranson, Hilary ORCID: https://orcid.org/0000-0003-2332-8247 and Hemingway, Janet ORCID: https://orcid.org/0000-0002-3200-7173 (2007) 'Mutated sodium channel genes and elevated monooxygenases are found in pyrethroid resistant populations of Sri Lankan malaria vectors'. Pesticide Biochemistry and Physiology, Vol 88, Issue 1, pp. 108-113.

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Abstract

The present status of pyrethroid resistance in vectors of malaria; Anopheles culicifacies and Anopheles subpictus, was tested in two malarious Districts, Anuradhapura and Trincomalee, of Sri Lanka. Both species were resistant to permethrin and susceptible to cypermethrin and cyfluthrin. An. subpictus were resistant to deltamethrin. lambda-Cyhalothrin and etofenprox resistance was shown only by Anuradhapura An. subpictus. Although there were no differences among the populations for esterase and glutathione S-transferase activities, increased monooxygenase levels were found among Trincomalee populations. The voltage-gated sodium channel gene, the target site gene of pyrethroids, was partially sequenced to screen for mutations previously associated with insecticide resistance. The classic leucine to phenylalanine substitution, TTA to TTT, was detected in An. subpictus. It appears that both kdr type and monooxygenase resistance underlie pyrethroid resistance in these two malaria vectors of Sri Lanka. (c) 2006 Elsevier Inc. All rights reserved.

Item Type:	Article
Uncontrolled Keywords:	pyrethroid resistance malaria vectors anopheles culicifacies anopheles subpictus kdr monooxygenases glutathione s-transferases insecticide resistance knockdown resistance anopheles-subpictus culex-quinquefasciatus ddt-resistance culicidae diptera kdr culicifacies
Subjects:	QU Biochemistry > Genetics > QU 450 General Works QX Parasitology > Insects. Other Parasites > QX 515 Anopheles QX Parasitology > Insects. Other Parasites > QX 600 Insect control. Tick control QX Parasitology > Insects. Other Parasites > QX 650 Insect vectors
Faculty: Department:	Groups (2002 - 2012) > Vector Group
Digital Object Identifer (DOI):	https://doi.org/10.1016/j.pestbp.2006.10.001
Depositing User:	Ms Julia Martin
Date Deposited:	06 Sep 2010 15:30
Last Modified:	30 Aug 2019 17:05
URI:	https://archive.lstmed.ac.uk/id/eprint/1362

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