Safety Considerations for Malaria Volunteer Infection Studies: A Mini-Review

Odedra, Anand and McCarthy, James S. (2020) 'Safety Considerations for Malaria Volunteer Infection Studies: A Mini-Review'. American Journal of Tropical Medicine and Hygiene, Vol 102, Issue 5, pp. 934-939.

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Abstract

Malaria clinical studies entailing the experimental infection of healthy volunteers with Plasmodium parasites by bites from infected mosquitos, injection of cryopreserved sporozoites, or injection of blood stage parasites provide valuable information for vaccine and drug development. Success of these studies depends on maintaining safety. In this mini-review, we discuss the safety risks and associated mitigation strategies of these three types of experimental malaria infection. We aim to inform researchers and regulators who are currently involved in or are planning to establish experimental malaria infection studies in endemic or non-endemic settings.

Item Type:	Article
Subjects:	QV Pharmacology > Drug Standardization. Pharmacognosy. Medicinal Plants > QV 771 Standardization and evaluation of drugs QX Parasitology > Protozoa > QX 135 Plasmodia WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria WC Communicable Diseases > Tropical and Parasitic Diseases > WC 765 Prevention and control
Faculty: Department:	Biological Sciences > Department of Tropical Disease Biology
Digital Object Identifer (DOI):	https://doi.org/10.4269/ajtmh.19-0351
Depositing User:	Marie Hatton
Date Deposited:	20 Mar 2020 16:44
Last Modified:	16 Mar 2021 02:02
URI:	https://archive.lstmed.ac.uk/id/eprint/14034

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