Neutrophil function is impaired in paediatric patients with malignancy and may be a useful clinical marker

Reiné, Jesús, Cooper, K., Sewell, A., Lyall, J., Thorbinson, C., Hincks, E., Ferreira, Daniela ORCID: https://orcid.org/0000-0002-0594-0902, Pizer, B. and Morton, Ben ORCID: https://orcid.org/0000-0002-6164-2854 (2020) 'Neutrophil function is impaired in paediatric patients with malignancy and may be a useful clinical marker'. Clinical and Translational Oncology, Vol 22, pp. 2121-2125.

Text Reiné J et al, Clin Trans Oncol 2020.pdf - Published Version Restricted to Repository staff only Download (634kB)

Abstract

Purpose
Patients treated with cytotoxic chemotherapy are at risk of neutropenia, neutropenic fever and neutropenic sepsis. We hypothesised that pre-existing neutrophil function dysfunction may increase susceptibility to neutropenic fever in paediatric patients receiving cytotoxic chemotherapy.

Methods
Prospective cohort study recruited patients at Alder Hey Children’s NHS Foundation Trust, United Kingdom. We measured neutrophil phagocytic function using a validated flow cytometric whole blood phagocytosis assay in paediatric patients (n = 16) with oncological disease before and after chemotherapy in a prospective cohort study. We recruited healthy children as a control comparator (n = 10).

Results
We found significantly decreased phagocytic function in oncology patients compared to healthy participants. In five patients who developed neutropenic fever, we observed increased pre-dose neutrophil respiratory burst.

Conclusion
With further validation, measurement of neutrophil function could potentially be used to personalise appropriate prophylactic antimicrobial administration for patients receiving cytotoxic chemotherapy.

Item Type:	Article
Subjects:	QW Microbiology and Immunology > Immunity by Type > QW 568 Cellular immunity. Immunologic cytotoxicity. Immunocompetence. Immunologic factors (General) QZ Pathology > Neoplasms. Cysts > QZ 200 Neoplasms. Cysts (General) WH Hemic and Lymphatic Systems > Hematologic Diseases. Immunologic Factors. Blood Banks > WH 200 Leukocytes. Leukocyte disorders (General) WS Pediatrics > WS 100 General works
Faculty: Department:	Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI):	https://doi.org/10.1007/s12094-020-02362-2
Depositing User:	Stacy Murtagh
Date Deposited:	27 May 2020 17:18
Last Modified:	29 Oct 2020 11:08
URI:	https://archive.lstmed.ac.uk/id/eprint/14560

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