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Wolbachia- and Onchocerca volvulus-induced keratitis (River blindness) is dependent on myeloid differentiation factor 88

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Gillette-Ferguson, I., Hise, A. G., Sun, Y., Diaconu, E., McGarry, Helen F., Taylor, Mark ORCID: https://orcid.org/0000-0003-3396-9275 and Pearlman, E. (2006) 'Wolbachia- and Onchocerca volvulus-induced keratitis (River blindness) is dependent on myeloid differentiation factor 88'. Infection and Immunity, Vol 74, Issue 4, pp. 2442-2445.

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Official URL: http://iai.asm.org/cgi/content/abstract/74/4/2442

Abstract

Endosymbiotic Wolbachia bacteria that infect the filarial nematode Onchocerca volvulus were previously found to have an essential role in the pathogenesis of river blindness. The current study demonstrates that corneal inflammation induced by Wolbachia or O. volvulus antigens containing Wolbachia is completely dependent on expression of myeloid differentiation factor 88.

Item Type:	Article
Uncontrolled Keywords:	helminth-mediated keratitis toll-like receptors bacterial endosymbionts corneal inflammation filarial nematodes surface protein brugia-malayi neutrophil responses antibody
Subjects:	QX Parasitology > Helminths. Annelida > QX 200 Helminths QX Parasitology > Helminths. Annelida > QX 301 Filarioidea WC Communicable Diseases > Tropical and Parasitic Diseases > WC 850 Nematode infections (General) WC Communicable Diseases > Tropical and Parasitic Diseases > WC 885 Onchocerciasis
Faculty: Department:	Groups (2002 - 2012) > Molecular & Biochemical Parasitology Group
Digital Object Identifer (DOI):	https://doi.org/10.1128/IAI.74.4.2442-2445.2006
Depositing User:	Sarah Lewis-Newton
Date Deposited:	17 May 2011 09:10
Last Modified:	16 Sep 2019 09:00
URI:	https://archive.lstmed.ac.uk/id/eprint/1489

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