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Li, Shanshan, Mi, Baibing, Qu, Pengfei, Liu, Danmeng, Lei, Fangliang, Wang, Duolao 
ORCID: https://orcid.org/0000-0003-2788-2464, Zeng1, Lingxia, Kang, Yijun, Shen, Yuan, Pei, Leilei, Yan, Hong, Liu, Xin and Dang, Shaonong
(2021)
'Association of antenatal vitamin B complex supplementation with neonatal vitamin B12 status: evidence from a cluster randomized controlled trial'. European Journal of Nutrition, Vol 60, Issue 3, pp. 1031-1039.
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Abstract
Purpose
Evidence about the effect of maternal vitamin B12 supplementation on offspring’s vitamin B12 status is limited. The present interventional study sought to evaluate the association of antenatal vitamin B complex supplementation with neonatal vitamin B12 status.
Methods
In an ongoing cluster randomized controlled trial conducted in three rural counties in northwest China, pregnant women < 20 weeks of gestation were randomized to three treatment groups: blank control, iron supplements, or vitamin B complex supplements. All women were administered folic acid supplements during the periconceptional period. In a sub-study, we collected cord blood samples of 331 participants from the control or vitamin B complex groups in the Xunyi county from January 2017 to December 2017. Plasma concentrations of folate, vitamin B12, and homocysteine were measured. Linear mixed models with a random intercept for cluster were used to compare biochemical indexes between groups after controlling for covariates.
Results
Compared with newborns whose mothers were in the control group, newborns of the vitamin B complex-supplemented women had significantly higher cord plasma vitamin B12 (P = 0.001) and lower homocysteine concentrations (P = 0.043). The association of antenatal vitamin B complex supplementation with cord blood vitamin B12 concentrations appeared to be more pronounced among newborns with high folate status than those with low folate status (Pinteraction = 0.060).
Conclusions
Maternal vitamin B complex supplementation during pregnancy was associated with better neonatal vitamin B12 status in rural northwest China.
| Item Type: | Article |
|---|---|
| Subjects: | QU Biochemistry > Vitamins > QU 145.5 Nutritive values of food QU Biochemistry > Vitamins > QU 160 Vitamins. Vitamin requirements WA Public Health > Health Problems of Special Population Groups > WA 310 Maternal welfare WD Disorders of Systemic, Metabolic or Environmental Origin, etc > Nutrition Disorders > WD 100 General works WQ Obstetrics > Childbirth. Prenatal Care > WQ 175 Prenatal care |
| Faculty: Department: | Clinical Sciences & International Health > Clinical Sciences Department |
| Digital Object Identifer (DOI): | https://doi.org/10.1007/s00394-020-02309-x |
| Depositing User: | Claire McIntyre |
| Date Deposited: | 06 Jul 2020 11:20 |
| Last Modified: | 23 Jun 2021 01:02 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/14921 |
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