Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0

Percie du Sert, Nathalie, Ahluwalia, Amrita, Alam, Sabina, Avey, Marc T., Baker, Monya, Browne, William J., Clark, Alejandra, Cuthill, Innes C., Dirnagl, Ulrich, Emerson, Michael, Garner, Paul ORCID: https://orcid.org/0000-0002-0607-6941, Holgate, Stephen T., Howells, David W., Hurst, Viki, Karp, Natasha A., Lazic, Stanley E., Lidster, Katie, MacCallum, Catriona J., Macleod, Malcolm, Pearl, Esther J., Petersen, Ole H., Rawle, Frances, Reynolds, Penny, Rooney, Kieron, Sena, Emily S., Silberberg, Shai D., Steckler, Thomas and Würbel, Hanno (2020) 'Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0'. PLoS Biology, Vol 18, Issue 7, e3000411.

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Abstract

Improving the reproducibility of biomedical research is a major challenge. Transparent and accurate reporting is vital to this process; it allows readers to assess the reliability of the findings and repeat or build upon the work of other researchers. The ARRIVE guidelines (Animal Research: Reporting In Vivo Experiments) were developed in 2010 to help authors and journals identify the minimum information necessary to report in publications describing in vivo experiments. Despite widespread endorsement by the scientific community, the impact of ARRIVE on the transparency of reporting in animal research publications has been limited. We have revised the ARRIVE guidelines to update them and facilitate their use in practice. The revised guidelines are published alongside this paper. This explanation and elaboration document was developed as part of the revision. It provides further information about each of the 21 items in ARRIVE 2.0, including the rationale and supporting evidence for their inclusion in the guidelines, elaboration of details to report, and examples of good reporting from the published literature. This document also covers advice and best practice in the design and conduct of animal studies to support researchers in improving standards from the start of the experimental design process through to publication.

Item Type:	Article
Subjects:	QY Clinical Pathology > QY 25 Laboratory techniques and procedure W General Medicine. Health Professions > W 20.5 Biomedical research W General Medicine. Health Professions > W 20.55.V4 Veterinary biomedical research WB Practice of Medicine > WB 60 Bioethics. Clinical ethics. Clinical ethics committees
Faculty: Department:	Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI):	https://doi.org/10.1371/journal.pbio.3000411
SWORD Depositor:	JISC Pubrouter
Depositing User:	Stacy Murtagh
Date Deposited:	15 Jul 2020 10:58
Last Modified:	03 Aug 2020 09:24
URI:	https://archive.lstmed.ac.uk/id/eprint/15044

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