Newton, P. N., Ward, Stephen ORCID: https://orcid.org/0000-0003-2331-3192, Angus, B. J., Chierakul, W., Dondorp, A., Ruangveerayuth, R., Silamut, K., Teerapong, P., Suputtamongkol, Y., Looareesuwan, S. and White, N. J. (2006) 'Early treatment failure in severe malaria resulting from abnormally low plasma quinine concentrations'. Transactions of the Royal Society of Tropical Medicine and Hygiene, Vol 100, Issue 2, pp. 184-186.
Full text not available from this repository.Abstract
A patient admitted with severe Plasmodium falciparum malaria in western Thailand had an early treatment failure with quinine, despite full dosing. Plasma quinine concentrations were subtherapeutic. Abnormal quinine pharmacokinetics may explain sporadic reports of quinine treatment failures in severe malaria. (C) 2005 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.
Item Type: | Article |
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Uncontrolled Keywords: | malaria plasmodium falciparum quinine pharmacokinetics treatment failure thailand uncomplicated falciparum-malaria plasmodium-falciparum pharmacokinetics resistance thailand |
Subjects: | QV Pharmacology > Anti-Inflammatory Agents. Anti-Infective Agents. Antineoplastic Agents > QV 256 Antimalarials QV Pharmacology > QV 38 Drug action. QX Parasitology > Protozoa > QX 135 Plasmodia WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria |
Faculty: Department: | Groups (2002 - 2012) > Molecular & Biochemical Parasitology Group |
Digital Object Identifer (DOI): | https://doi.org/10.1016/j.trstmh.2005.01.008 |
Depositing User: | Martin Chapman |
Date Deposited: | 15 Mar 2011 14:46 |
Last Modified: | 06 Feb 2018 13:02 |
URI: | https://archive.lstmed.ac.uk/id/eprint/1561 |
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