Differential expression of the detoxification genes in the different life stages of the malaria vector Anopheles gambiae

Strode, Clare, Steen, Keith ORCID: https://orcid.org/0000-0002-8933-8643, Ortelli, Federica and Ranson, Hilary ORCID: https://orcid.org/0000-0003-2332-8247 (2006) 'Differential expression of the detoxification genes in the different life stages of the malaria vector Anopheles gambiae'. Insect Molecular Biology, Vol 15, Issue 4, pp. 523-530.

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Abstract

The diverse habitats and diets encountered during the life cycle of an Anopheles mosquito have necessitated the development of extensive families of detoxification enzymes. Expansion of the three detoxification enzyme families (cytochrome P450s, carboxylesterases and glutathione transfereases), has occurred in mosquitoes compared with Drosophila, however, very little is known regarding the developmental expression of theses genes. Using a custom made microarray we determined the expression profile of the detoxification genes in adults, larvae and pupae of the malaria vector A. gambiae. The expression of approximately one quarter of these genes was developmentally regulated. The expression profile of each of these genes and the information this data provides on putative functions of the mosquito detoxification enzymes is discussed.

Item Type:	Article
Uncontrolled Keywords:	mosquito microarray detoxification enzymes environment life stage glutathione s-transferases drosophila-melanogaster insecticide-resistance ecdysteroidogenic pathway bombyx-mori p450 enzyme leaf-litter cytochrome-p450 ecdysone hormone
Subjects:	QW Microbiology and Immunology > QW 45 Microbial drug resistance. General or not elsewhere classified. QX Parasitology > Insects. Other Parasites > QX 510 Mosquitoes QX Parasitology > Insects. Other Parasites > QX 515 Anopheles QX Parasitology > Insects. Other Parasites > QX 650 Insect vectors WA Public Health > Preventive Medicine > WA 240 Disinfection. Disinfestation. Pesticides (including diseases caused by) WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria
Faculty: Department:	Groups (2002 - 2012) > Vector Group
Digital Object Identifer (DOI):	https://doi.org/10.1111/j.1365-2583.2006.00667.x
Depositing User:	Sarah Lewis-Newton
Date Deposited:	17 Feb 2011 11:42
Last Modified:	30 Aug 2019 17:05
URI:	https://archive.lstmed.ac.uk/id/eprint/1601

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