Trypa-NO! contributes to the elimination of gambiense human African trypanosomiasis by combining tsetse control with “screen, diagnose and treat” using innovative tools and strategies

Ndung’u, Joseph Mathu, Boulangé, Alain, Picado, Albert, Mugenyi, Albert, Mortensen, Allan, Hope, Andrew, Mollo, Brahim Guihini, Bucheton, Bruno, Wamboga, Charles, Waiswa, Charles, Kaba, Dramane, Matovu, Enock, Courtin, Fabrice, Garrod, Gala, Gimonneau, Geoffrey, Bingham, Georgina V., Hassane, Hassane Mahamat, Tirados, Inaki ORCID: https://orcid.org/0000-0002-9771-4880, Saldanha, Isabel, Kabore, Jacques, Rayaisse, Jean-Baptiste, Bart, Jean-Mathieu, Lingley, Jessica, Esterhuizen, Johan, Longbottom, Joshua, Pulford, Justin ORCID: https://orcid.org/0000-0003-4756-8480, Kouakou, Lingue, Sanogo, Lassina, Cunningham, Lucas, Camara, Mamadou, Koffi, Mathurin, Stanton, Michelle ORCID: https://orcid.org/0000-0002-1754-4894, Lehane, Mike, Kagbadouno, Moise Saa, Camara, Oumou, Bessell, Paul, Mallaye, Peka, Solano, Philippe, Selby, Richard, Dunkley, Sophie, Torr, Steve ORCID: https://orcid.org/0000-0001-9550-4030, Biéler, Sylvain, Lejon, Veerle, Jamonneau, Vincent, Yoni, Wilfried and Katz, Zachary (2020) 'Trypa-NO! contributes to the elimination of gambiense human African trypanosomiasis by combining tsetse control with “screen, diagnose and treat” using innovative tools and strategies'. PLoS Neglected Tropical Diseases, Vol 14, Issue 11, e0008738.

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Abstract

Gambiense human African trypanosomiasis (g-HAT) is the chronic form of sleeping sickness caused by Trypanosoma brucei gambiense in West and Central Africa, while Trypanosoma brucei rhodesiense causes an acute form in eastern Africa. g-HAT is targeted for elimination as a public health problem by 2020 and 0 transmission by 2030 [1,2]. Control of g-HAT is largely based on identification and treatment of infected individuals, supplemented by control of the tsetse fly vectors [3]. There has been growing evidence that when both tsetse control and case identification activities are carried out simultaneously in the same geographies, elimination of the disease is accelerated [4–6]. Here, we describe how the Trypa-NO! Partnership is using novel and classical tools to drive g-HAT elimination in an integrated approach, progress made, lessons learnt, and future directions.

Item Type:	Article
Subjects:	QX Parasitology > Insects. Other Parasites > QX 505 Diptera WA Public Health > Preventive Medicine > WA 110 Prevention and control of communicable diseases. Transmission of infectious diseases WA Public Health > Health Problems of Special Population Groups > WA 395 Health in developing countries WC Communicable Diseases > Tropical and Parasitic Diseases > WC 705 Trypanosomiasis
Faculty: Department:	Biological Sciences > Department of Tropical Disease Biology Biological Sciences > Vector Biology Department
Digital Object Identifer (DOI):	https://doi.org/10.1371/journal.pntd.0008738
SWORD Depositor:	JISC Pubrouter
Depositing User:	Stacy Murtagh
Date Deposited:	13 Nov 2020 12:27
Last Modified:	09 Dec 2020 11:56
URI:	https://archive.lstmed.ac.uk/id/eprint/16087

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