Prospects for the treatment of drug-resistant malaria parasites

Tilley, L., Davis, T. M. E. and Bray, Patrick (2006) 'Prospects for the treatment of drug-resistant malaria parasites'. Future Microbiology, Vol 1, Issue 1, pp. 127-141.

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Abstract

Widespread parasitic resistance has led to an urgent need for the development and implementation of new drugs for the treatment of Plasmodium foiciparum malaria. Artemisinin and its derivatives are becoming increasingly important, used preferably in combination with a second antimalarial agent to increase the efficacy and slow the development of resistance. However, cost, production and pharmacological issues associated with artemisinin derivatives and potential partner drugs are hindering the implementation of combination therapies. This article reviews the molecular basis of the action of, and resistance to, different antimalarials and examines the prospects for the next generation of drugs to combat this potentially lethal human pathogen.

Item Type:	Article
Uncontrolled Keywords:	antimalarials artemisinin combination therapy chloroquine drug resistance endoperoxide malaria pfcrt quinolines plasmodium-falciparum malaria drug/metabolite transporter superfamily artemisinin combination therapy transmembrane protein pfcrt chloroquine resistance antimalarial-drug quinoline antimalarials uncomplicated malaria in-vitro artemether-lumefantrine
Subjects:	QW Microbiology and Immunology > QW 45 Microbial drug resistance. General or not elsewhere classified. WC Communicable Diseases > Tropical and Parasitic Diseases > WC 700 Protozoan infections (General) WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria
Faculty: Department:	Groups (2002 - 2012) > Molecular & Biochemical Parasitology Group
Digital Object Identifer (DOI):	https://doi.org/10.2217/17460913.1.1.127
Depositing User:	Martin Chapman
Date Deposited:	10 May 2011 17:25
Last Modified:	17 Jul 2020 10:57
URI:	https://archive.lstmed.ac.uk/id/eprint/1616

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