Pneumococcal colonization impairs mucosal immune responses to Live Attenuated Influenza Vaccine in adults

Carniel, Beatriz, Marcon, Fernando, Rylance, Jamie ORCID: https://orcid.org/0000-0002-2323-3611, German, Esther, Zaidi, Seher, Reiné, Jesús, Negera, Edessa, Nikolaou, Elissavet, Pojar, Sherin ORCID: https://orcid.org/0000-0002-7746-3279, SolorzanoGonzalez, Carla, Collins, Andrea ORCID: https://orcid.org/0000-0002-4094-1572, Connor, Victoria, Bogaert, Debbie, Gordon, Stephen ORCID: https://orcid.org/0000-0001-6576-1116, Nakaya, Helder I, Ferreira, Daniela ORCID: https://orcid.org/0000-0002-0594-0902, Jochems, Simon ORCID: https://orcid.org/0000-0002-4835-1032 and Mitsi, Elena (2021) 'Pneumococcal colonization impairs mucosal immune responses to Live Attenuated Influenza Vaccine in adults'. JCI insight, Vol 6, Issue 4, p. 141088.

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Abstract

Influenza virus infections affect millions of people annually. Current available vaccines provide varying rates of protection. There is a knowledge gap on how the nasal microbiota, particularly established pneumococcal colonization, shapes the response to influenza vaccination. In this study, we inoculated healthy adults with live S. pneumoniae and vaccinated them three days later with either TIV or LAIV. Vaccine-induced immune responses were assessed in nose, blood and lung. Nasal pneumococcal colonization had no impact upon TIV-induced antibody responses to influenza, which manifested in all compartments. However, experimentally induced pneumococcal colonization dampened LAIV-mediated mucosal antibody responses, primarily IgA in the nose and IgG in the lung. Pulmonary influenza-specific cellular responses were more apparent in the LAIV group compared to either TIV or an unvaccinated group. These results indicate that TIV and LAIV elicit differential immunity to adults and that LAIV immunogenicity is diminished by the nasal presence of S. pneumoniae. Therefore, nasopharyngeal pneumococcal colonization may affect LAIV efficacy.

Item Type:	Article
Subjects:	QW Microbiology and Immunology > Immunity by Type > QW 563 Local immunity QW Microbiology and Immunology > Immunotherapy and Hypersensitivity > QW 805 Vaccines. Antitoxins. Toxoids WC Communicable Diseases > Infection. Bacterial Infections > Bacterial Infections > WC 217 Pneumococcal infections WC Communicable Diseases > Virus Diseases > Viral Respiratory Tract Infections. Respirovirus Infections > WC 515 Human influenza
Faculty: Department:	Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI):	https://doi.org/10.1172/jci.insight.141088
Depositing User:	Julie Franco
Date Deposited:	27 Jan 2021 11:52
Last Modified:	23 Feb 2021 12:32
URI:	https://archive.lstmed.ac.uk/id/eprint/16770

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