Association between the pfmdr1 gene and in vitro artemether and lumefantrine sensitivity in Thai isolates of Plasmodium falciparum.

Mungthin, Mathirut, Khositnithikul, Rommanee, Sitthichot, Naruemon, Suwandittakul, Nantana, Wattanaveeradej, Veerachai, Ward, Steve ORCID: https://orcid.org/0000-0003-2331-3192 and Na-Bangchang, Kesara (2010) 'Association between the pfmdr1 gene and in vitro artemether and lumefantrine sensitivity in Thai isolates of Plasmodium falciparum.'. American Journal of Tropical Medicine and Hygiene, Vol 83, Issue 5, pp. 1005-1009.

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Abstract

We evaluated the influence of pfmdr1 mutations and copy number on in vitro artemether and lumefantrine sensitivity in 101 laboratory and adapted Thai isolates of Plasmodium falciparum. Approximately one-fourth of these isolates exhibited reduced lumefantrine susceptibility. We found that both mutations and amplification of the pfmdr1 gene influenced in vitro artemether and lumefantrine sensitivity. Using multivariate analysis, 184F or 1042N alleles and a copy number of ≥ 4 were identified as the independent markers for decreased lumefantrine susceptibility. Separate analysis also indicated that parasites from different geographical areas were influenced by different genetic markers.

Item Type:	Article
Subjects:	QV Pharmacology > Anti-Inflammatory Agents. Anti-Infective Agents. Antineoplastic Agents > QV 256 Antimalarials QX Parasitology > Protozoa > QX 135 Plasmodia WC Communicable Diseases > Tropical and Parasitic Diseases > WC 770 Therapy
Digital Object Identifer (DOI):	https://doi.org/10.4269/ajtmh.2010.10-0339
Depositing User:	Mary Creegan
Date Deposited:	11 Feb 2011 16:22
Last Modified:	28 Sep 2018 15:35
URI:	https://archive.lstmed.ac.uk/id/eprint/1732

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