Isolation and Characterisation of Bacteriophages with Activity against Invasive Non-Typhoidal Causing Bloodstream Infection in Malawi

Rodwell, Ella V, Wenner, Nicolas, Pulford, Caisey V, Cai, Yueyi, Bowers-Barnard, Arthur, Beckett, Alison, Rigby, Jonathan, Picton, David M, Blower, Tim R, Feasey, Nicholas ORCID: https://orcid.org/0000-0003-4041-1405, Hinton, Jay C D and Perez-Sepulveda, Blanca M (2021) 'Isolation and Characterisation of Bacteriophages with Activity against Invasive Non-Typhoidal Causing Bloodstream Infection in Malawi'. Viruses, Vol 13, Issue 3, p. 478.

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Abstract

In recent years, novel lineages of invasive non-typhoidal (iNTS) serovars Typhimurium and Enteritidis have been identified in patients with bloodstream infection in Sub-Saharan Africa. Here, we isolated and characterised 32 phages capable of infecting . Typhimurium and . Enteritidis, from water sources in Malawi and the UK. The phages were classified in three major phylogenetic clusters that were geographically distributed. In terms of host range, Cluster 1 phages were able to infect all bacterial hosts tested, whereas Clusters 2 and 3 had a more restricted profile. Cluster 3 contained two sub-clusters, and 3.b contained the most novel isolates. This study represents the first exploration of the potential for phages to target the lineages of that are responsible for bloodstream infections in Sub-Saharan Africa.

Item Type:	Article
Subjects:	QW Microbiology and Immunology > Bacteria > QW 138 Enterobacteriaceae WA Public Health > Health Problems of Special Population Groups > WA 395 Health in developing countries WC Communicable Diseases > Infection. Bacterial Infections > Bacterial Infections > WC 240 Bacteremia. Sepsis. Toxemias WC Communicable Diseases > Infection. Bacterial Infections > Enteric Infections > WC 269 Salmonella infections
Faculty: Department:	Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI):	https://doi.org/10.3390/v13030478
Depositing User:	Julie Franco
Date Deposited:	13 Apr 2021 13:56
Last Modified:	13 Apr 2021 13:56
URI:	https://archive.lstmed.ac.uk/id/eprint/17495

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