A polymorphism of intercellular adhesion molecule-1 is associated with a reduced incidence of nonmalarial febrile illness in Kenyan children

Jenkins, N., Mwangi, T. W., Kortok, M., Marsh, Kevin, Craig, Alister ORCID: https://orcid.org/0000-0003-0914-6164 and Williams, T. N. (2005) 'A polymorphism of intercellular adhesion molecule-1 is associated with a reduced incidence of nonmalarial febrile illness in Kenyan children'. Clinical Infectious Diseases, Vol 41, Issue 12, pp. 1817-1819.

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Abstract

An intercellular adhesion molecule-1 polymorphism (ICAM-1(Kilifi)) is present at a high frequency across sub-Saharan Africa, and its presence may increase susceptibility to cerebral malaria. Here, we report that, compared with children in whom wild-type intercellular adhesion molecule-1 is present, the incidence of nonmalarial fever is significantly lower among those homozygous for ICAM-1(Kilifi). We propose that ICAM-1(Kilifi) may be associated with reduced rates of tissue damage and of death due to sepsis.

Item Type:	Article
Uncontrolled Keywords:	severe malaria icam-1 icam-1(kilifi) mice
Subjects:	QX Parasitology > Protozoa > QX 135 Plasmodia WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria WS Pediatrics > Diseases of Children and Adolescents > General Diseases > WS 200 General works
Digital Object Identifer (DOI):	https://doi.org/10.1086/498156
Depositing User:	Ms Julia Martin
Date Deposited:	12 May 2011 09:18
Last Modified:	17 Jul 2019 14:14
URI:	https://archive.lstmed.ac.uk/id/eprint/1869

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