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Thirteen-Valent Pneumococcal Conjugate Vaccine–Induced Immunoglobulin G (IgG) Responses in Serum Associated With Serotype-Specific IgG in the Lung

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Mitsi, Elena, McLenaghan, Daniella, Wolf, Asia-Sophia, Jones, Scott, Collins, Andrea ORCID: https://orcid.org/0000-0002-4094-1572, Hyder-Wright, Angela, Goldblatt, David, Heyderman, Robert, Gordon, Stephen ORCID: https://orcid.org/0000-0001-6576-1116 and Ferreira, Daniela ORCID: https://orcid.org/0000-0002-0594-0902 (2022) 'Thirteen-Valent Pneumococcal Conjugate Vaccine–Induced Immunoglobulin G (IgG) Responses in Serum Associated With Serotype-Specific IgG in the Lung'. Journal of Infectious Disease, Vol 225, Issue 9, pp. 1626-1631.

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Official URL: https://academic.oup.com/jid/advance-article/doi/1...

Abstract

Pneumococcal conjugate vaccine (PCV) efficacy is lower for noninvasive pneumonia than invasive disease. In this study, participants were immunized with 13-valent PCV (PCV13) or hepatitis A vaccine (control). Bronchoalveolar lavage samples were taken between 2 and 6 months and serum at 4 and 7 weeks postvaccination. In the lung, anti-capsular immunoglobulin G (IgG) levels were higher in the PCV13 group compared to controls for all serotypes, except 3 and 6B. Systemically, IgG levels were elevated in the PCV13 group at 4 weeks for all serotypes, except serotype 3. IgG in bronchoalveolar lavage and serum positively correlated for nearly all serotypes. PCV13 shows poor immunogenicity to serotype 3, implying lack of protective efficacy.

Item Type:	Article
Subjects:	QW Microbiology and Immunology > Bacteria > QW 142 Gram-positive bacteria (General) QW Microbiology and Immunology > Antigens and Antibodies. Toxins and Antitoxins > QW 575 Antibodies QY Clinical Pathology > QY 4 General works WC Communicable Diseases > Infection. Bacterial Infections > Bacterial Infections > WC 217 Pneumococcal infections
Faculty: Department:	Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI):	https://doi.org/10.1093/infdis/jiab331
Depositing User:	Julie Franco
Date Deposited:	19 Aug 2021 14:08
Last Modified:	05 May 2022 13:18
URI:	https://archive.lstmed.ac.uk/id/eprint/18691

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