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Hay, Charles A, Prior, James, Mallen, Christian D, Belcher, John and Roddy, Ed (2022) 'Reply to Dr. Lai regarding Allopurinol Hypersensitivity Syndrome in patients of Asian ancestry'. Arthritis Care & Research, Vol 74, Issue 1, pp. 161-163.
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Abstract
We thank Dr Lai for their interest in our study (1). While we did not show a statistically significant link between the use of allopurinol and mortality in people with gout, we agree that Allopurinol Hypersensitivity Syndrome (AHS) is the most serious side-effect of allopurinol, particularly in populations with South East Asian ancestry, leading to the recommendation to screen people of South East Asian descent for the HLA-B*5801 allele prior to starting treatment with allopurinol (2,3).
| Item Type: | Article |
|---|---|
| Additional Information: | Letter to the Editor |
| Subjects: | QW Microbiology and Immunology > Immunotherapy and Hypersensitivity > QW 900 Anaphylaxis and hypersensitivity. Allergens |
| Faculty: Department: | Clinical Sciences & International Health > International Public Health Department |
| Digital Object Identifer (DOI): | https://doi.org/10.1002/acr.24777 |
| Depositing User: | Rachel Dominguez |
| Date Deposited: | 28 Sep 2021 15:00 |
| Last Modified: | 03 Sep 2022 01:02 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/18986 |
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