Kinetics of anti-SARS-CoV-2 IgG antibody levels and potential influential factors in subjects with COVID-19: A 11-month follow-up study

Luo, Huanyuan, Camilleri, Dorothée, Garitaonandia, Ibon, Djumanov, Dilshat, Chen, Tao ORCID: https://orcid.org/0000-0002-5489-6450, Lorch, Ulrike, Täubel, Jörg and Wang, Duolao ORCID: https://orcid.org/0000-0003-2788-2464 (2021) 'Kinetics of anti-SARS-CoV-2 IgG antibody levels and potential influential factors in subjects with COVID-19: A 11-month follow-up study'. Diagnostic Microbiology and Infectious Disease, Vol 101, Issue 4, p. 115537.

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Abstract

We aim to study kinetics of anti-SARS-CoV-2 IgG antibody levels in subjects with COVID-19 for up to 11 months and the potential influential factors. The study was a prospective longitudinal study. The analyses were based on 77 serum/plasma samples with a mean of 4 samples per participant (range 1 – 18) in 20 participants with at least one positive Polymerase Chain Reaction testing result from 19 March 2020 up to 10 February 2021. Among the subjects (median age 34.5 years, 65% male), IgG level declined with the follow-up time (per month; geometric mean ratio [GMR] 0.73; 95% CI, 0.72 – 0.74). In a small sample of subjects from the general population with COVID-19, IgG levels declined non-linearly from month 2 to 11 with individual heterogeneity in quantity and changing speed and may be associated with gender, race and the loss of smell and taste.

Item Type:	Article
Subjects:	QU Biochemistry > Genetics > QU 550 Genetic techniques. PCR. Chromosome mapping QW Microbiology and Immunology > Viruses > QW 160 Viruses (General). Virology QW Microbiology and Immunology > Antigens and Antibodies. Toxins and Antitoxins > QW 575 Antibodies
Faculty: Department:	Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI):	https://doi.org/10.1016/j.diagmicrobio.2021.115537
Depositing User:	Stacy Murtagh
Date Deposited:	08 Oct 2021 07:46
Last Modified:	09 Sep 2022 01:02
URI:	https://archive.lstmed.ac.uk/id/eprint/19123

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