Incidence of cardiometabolic diseases in people living with and without HIV in the UK: a population-based matched cohort study

Gooden, Tiffany E., Gardner, Mike, Wang, Jingya, Jolly, Kate, Lane, Deirdre A., Benjamin, Laura A., Mwandumba, Henry ORCID: https://orcid.org/0000-0003-4470-3608, Kandoole, Vanessa, Lwanga, Isaac B., Taylor, Stephen, Manaseki-Holland, Semira, Lip, Gregory Y.H., Nirantharakumar1, Krishnarajah and Thomas, G. Neil (2022) 'Incidence of cardiometabolic diseases in people living with and without HIV in the UK: a population-based matched cohort study'. Journal of Infectious Disease, Vol 225, Issue 8, pp. 1348-1356.

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Abstract

Background
Evidence on the risk of cardiovascular disease (CVD) and CVD risk factors in people with HIV (PWH) is limited. We aimed to identify the risk of composite CVD, individual CVD events and common risk factors.

Methods
This was a nationwide population-based cohort study comparing adult (≥18y) PWH with HIV-negative individuals matched on age, sex, ethnicity and location. The primary outcome was composite CVD comprising stroke, myocardial infarction (MI), peripheral vascular disease (PVD), ischaemic heart disease and heart failure. The secondary outcomes were individual CVD events, hypertension, diabetes, chronic kidney disease (CKD) and all-cause mortality. Cox proportional hazard regression models were used to examine the risk of each outcome.

Results
We identified 9233 PWH and 35721 HIV-negative individuals. An increased risk was found for composite CVD (adjusted hazard ratio [aHR] 1.50, 95% CI 1.28-1.77), stroke (aHR 1.42, 95% CI 1.08-1.86), ischaemic heart disease (aHR 1.55, 95% CI 1.24-1.94), hypertension (aHR 1.37, 95% CI 1.23-1.53), type 2 diabetes (aHR 1.28, 95% CI 1.09-1.50), CKD (aHR 2.42, 95% CI 1.98-2.94) and all-cause mortality (aHR 2.84, 95% CI (2.48-3.25).

Conclusions
PWH have a heightened risk for CVD and common CVD risk factors, reinforcing the importance for regular screening for such conditions.

Item Type:	Article
Subjects:	WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503 Acquired immunodeficiency syndrome. HIV infections WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503.41 General coverage WG Cardiovascular System > Heart. Heart Diseases > WG 200 General works WJ Urogenital System > WJ 100 General works WK Endocrine System > WK 880 Hyperinsulinism. Hyperglycemia. Hypoglycemia
Faculty: Department:	Clinical Sciences & International Health > Malawi-Liverpool-Wellcome Programme (MLW)
Digital Object Identifer (DOI):	https://doi.org/10.1093/infdis/jiab420
Depositing User:	Claire McIntyre
Date Deposited:	12 Nov 2021 09:49
Last Modified:	05 May 2022 13:28
URI:	https://archive.lstmed.ac.uk/id/eprint/19407

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