Specific receptor usage in Plasmodium falciparum cytoadherence is associated with disease outcome.

Ochola, Lucy, Siddondo, Bethsheba R., Ocholla, Harold, Nkya, Siana, Kimani, Eva N, Williams, Thomas N., Makale, Johnstone O., Liljander, Anne, Urban, Britta ORCID: https://orcid.org/0000-0002-4197-8393, Bull, Pete C., Szestak, Tadge, Marsh, Kevin and Craig, Alister ORCID: https://orcid.org/0000-0003-0914-6164 (2011) 'Specific receptor usage in Plasmodium falciparum cytoadherence is associated with disease outcome.'. PLoS ONE, Vol 6, Issue 3, e14741.

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Abstract

Our understanding of the basis of severe disease in malaria is incomplete. It is clear that pathology is in part related to the pro-inflammatory nature of the host response but a number of other factors are also thought to be involved, including the interaction between infected erythrocytes and endothelium. This is a complex system involving several host receptors and a major parasite-derived variant antigen (PfEMP1) expressed on the surface of the infected erythrocyte membrane. Previous studies have suggested a role for ICAM-1 in the pathology of cerebral malaria, although these have been inconclusive. In this study we have examined the cytoadherence patterns of 101 patient isolates from varying clinical syndromes to CD36 and ICAM-1, and have used variant ICAM-1 proteins to further characterise this adhesive phenotype. Our results show that increased binding to CD36 is associated with uncomplicated malaria while ICAM-1 adhesion is raised in parasites from cerebral malaria cases.

Item Type:	Article
Subjects:	QZ Pathology > Manifestations of Disease > QZ 140 General manifestations of disease > QZ 150 Local reactions to injury and disease WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria
Faculty: Department:	Groups (2002 - 2012) > Molecular & Biochemical Parasitology Group
Digital Object Identifer (DOI):	https://doi.org/10.1371/journal.pone.0014741
Depositing User:	Mary Creegan
Date Deposited:	02 Jun 2011 11:46
Last Modified:	17 Jul 2019 14:14
URI:	https://archive.lstmed.ac.uk/id/eprint/2017

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