Crotaline snake bite in the Ecuadorian Amazon: randomised double blind comparative trial of three South American polyspecific antivenoms

Smalligan, R., Cole, J., Brito, N., Laing, Gavin, Mertz, B. L., Manock, S., Maudlin, J., Quist, B., Holland, G., Nelson, S., Lalloo, David ORCID: https://orcid.org/0000-0001-7680-2200, Rivadeneira, G., Barragan, M. E., Dolley, D., Eddleston, M., Warrell, D and Theakston, R.David G. (2004) 'Crotaline snake bite in the Ecuadorian Amazon: randomised double blind comparative trial of three South American polyspecific antivenoms'. British Medical Journal (BMJ), Vol 329, Issue 7475, pp. 1129-1133.

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Abstract

Objective To compare the efficacy and safety of three polyspecific antivenoms for bites from pit vipers.
Design Randomised double blind comparative trial of three antivenoms.
Setting Shell, Pastaza, southeastern Ecuador.
Participants 210 patients with incoagulable blood were recruited from 221 consecutive patients, admitted with snake bite between January 1997 and December 2001.
Intervention One of three antivenoms manufactured in Brazil, Colombia, and Ecuador, chosen for their preclinical potency against Ecuadorian venoms.
Main outcome measures Permanent restoration of blood coagulability after 6 and 24 hours.
Results The snakes responsible for the bites were identified in 187 cases: 109 patients (58%) were bitten by Bothrops atrox, 68 (36%) by B bilineatus, and 10 (5%) by B taeniatus, B brazili, or Lachesis muta. Eighty seven patients (41%) received Colombian antivenom, 82 (39%) received Brazilian antivenom, but only 41 (20%) received Ecuadorian antivenom because the supply was exhausted. Two patients died; and 10 developed local necrosis. All antivenoms achieved the primary end point of permanently restoring blood coagulability by 6 or 24 hours after the start of treatment in >40% of patients. Colombian antivenom, however, was the most effective after initial doses of 20 ml (two vials), < 70 ml, and any initial dose at both 6 and 24 hours. An initial dose of 20 ml of Colombian antivenom permanently restored blood coagulability in 64% (46/72) of patients after 6 hours (P = 0.054 compared with the other two antivenoms) and an initial dose of < 70 ml was effective at 6 hours (65%, P = 0.045) and 24 hours (99%, P = 0.06). Early anaphylactoid reactions were common (53%,73%, and 19%, respectively, for Brazilian, Colombian, and Ecuadorian antivenoms, P < 0.0001) but only three reactions were severe and none was fatal.
Conclusions All three antivenoms can be recommended for the treatment of snakebites in this region, though the reactogenicity of Brazilian and Colombian antivenoms is a cause for concern.

Item Type:	Article
Subjects:	WA Public Health > Preventive Medicine > WA 108 Preventive health services. Preventive medicine. Travel Medicine. WA Public Health > Accident and Injury Prevention. Disasters > WA 250 General works WD Disorders of Systemic, Metabolic or Environmental Origin, etc > Animal Poisons > WD 400 General works WD Disorders of Systemic, Metabolic or Environmental Origin, etc > Animal Poisons > WD 410 Reptiles
Digital Object Identifer (DOI):	https://doi.org/10.1136/bmj.329.7475.1129
Depositing User:	Sarah Lewis-Newton
Date Deposited:	10 Feb 2012 16:59
Last Modified:	14 Feb 2019 16:53
URI:	https://archive.lstmed.ac.uk/id/eprint/2135

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