New insights into the developmental biology and transmission mechanisms of Leishmania

Bates, Paul and Rogers, Matthew E. (2004) 'New insights into the developmental biology and transmission mechanisms of Leishmania'. Current Molecular Medicine, Vol 4, Issue 6, pp. 601-609.

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Abstract

Leishmania alternates between two main morphological forms in its life cycle: intracellular amastigotes in the mammalian host and motile promastigotes in the sandfly vector. Several different forms of promastigote can be recognised in sandfly infections. The first promastigote forms, which are found in the sandfly in the bloodmeal phase, are multiplicative procyclic promastigotes. These differentiate into nectomonad promastigotes, which are a non-dividing migratory stage moving from the posterior to the anterior midgut. When nectomonad promastigotes arrive at the anterior midgut they differentiate into leptomonad forms, a newly named life cycle stage, which resume replication. Leptomonad promastigotes, which are found in the anterior midgut, are the developmental precursors of the metacyclic promastigotes, the mammal-infective stages. Leptomonad forms also produce promastigote secretory gel, a substance that plays a key role in transmission by forming a physical obstruction in the gut, forcing the sandfly to regurgitate metacyclic promastigotes during bloodfeeding.

Item Type:	Article
Uncontrolled Keywords:	leishmania development life cycle sand fly promastigote transmission metacyclic vector lutzomyia-longipalpis sandflies phlebotomus-papatasi sand fly interactions in-vitro viannia braziliensis infective stage cutaneous leishmaniasis parasite transmission peritrophic matrix intermedia lutz
Subjects:	QX Parasitology > Insects. Other Parasites > QX 505 Diptera QX Parasitology > Insects. Other Parasites > QX 650 Insect vectors WC Communicable Diseases > Tropical and Parasitic Diseases > WC 715 Visceral leishmaniasis WR Dermatology > Parasitic Skin Diseases > WR 350 Tropical diseases of the skin. Mucocutaneous leishmaniasis. Leishmaniasis
Faculty: Department:	Groups (2002 - 2012) > Molecular & Biochemical Parasitology Group
Digital Object Identifer (DOI):	https://doi.org/10.2174/1566524043360285
Depositing User:	Sarah Lewis-Newton
Date Deposited:	28 Mar 2012 12:55
Last Modified:	17 Jul 2020 10:57
URI:	https://archive.lstmed.ac.uk/id/eprint/2143

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