CD45 variant alleles: possibly increased frequency of a novel exon 4 CD45 polymorphism in HIV seropositive Ugandans

Stanton, Tara, Boxall, Sally, Bennett, Andrea, Kaleebu, Pontiano, Watera, Christine, Whitworth, Jimmy, French, Neil, Dawes, Ritu, Hill, Adrian V. S., Bodmer, Walter, Beverley, Peter C. L. and Tchilian, Elma Z. (2004) 'CD45 variant alleles: possibly increased frequency of a novel exon 4 CD45 polymorphism in HIV seropositive Ugandans'. Immunogenetics, Vol 56, Issue 2, pp. 107-110.

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Abstract

The CD45 (leucocyte common) antigen is a haemopoietic cell specific tyrosine phosphatase essential for antigen receptor signalling in lymphocytes, and expression of different CD45 isoforms is associated with distinct functions. Here we describe a novel polymorphism in exon 4 (A54G) of the gene encoding CD45 (PTPRC) that results in an amino acid substitution of Thr-19 to Ala in exon 4. The 54G allele was identified in African Ugandan populations and was found with a suggestive but not statistically significant increase in frequency amongst HIV-seropositive Ugandans. This suggests that the 54G variant and CD45 splicing abnormalities might be associated with HIV infection.

Item Type:	Article
Uncontrolled Keywords:	cd45 hiv alternative splicing polymorphisms ugandan multiple-sclerosis point mutation cell maturation ptprc cd45 gene 77c->g mice
Subjects:	QW Microbiology and Immunology > Immunity by Type > QW 541 Natural immunity. Immunogenetics WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503 Acquired immunodeficiency syndrome. HIV infections
Digital Object Identifer (DOI):	https://doi.org/10.1007/s00251-004-0668-z
Depositing User:	Ms Julia Martin
Date Deposited:	23 Mar 2012 09:41
Last Modified:	21 Nov 2019 14:38
URI:	https://archive.lstmed.ac.uk/id/eprint/2158

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