alpha 1-acid glycoprotein and alpha 1-antitrypsin as early markers of treatment response in patients receiving the intensive phase of tuberculosis therapy

Almeida, M. L. D., Barbieri, M. A., Gurgel, R. Q., Abdurrahman, S. T., Baba, U. A., Hart, C. Anthony, Shenkin, A., Silva, A. M., de Souza, L. and Cuevas, Luis ORCID: https://orcid.org/0000-0002-6581-0587 (2009) 'alpha 1-acid glycoprotein and alpha 1-antitrypsin as early markers of treatment response in patients receiving the intensive phase of tuberculosis therapy'. Transactions of the Royal Society of Tropical Medicine and Hygiene, Vol 103, Issue 6, pp. 575-580.

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Abstract

The identification of early markers that predict the response to anti-tuberculosis treatment would facilitate evaluation of new drugs and improve patient management. This study aimed to determine whether selected acute phase proteins and micronutrients measured at the time of diagnosis and during the first weeks of treatment could predict treatment responses during the 2-month standard intensive phase of therapy. For this purpose, alpha 1-antitrypsin, alpha 1-acid gtycoprotein, alpha 2-macroglobutin, C-reactive protein, C3, C4, zinc, copper and selenium concentrations were measured in Brazilian patients with smear-positive tuberculosis at the time of diagnosis and 1, 3, 5 and 8 weeks after initiation of therapy. Patients were classified into fast (n = 29), intermediate (n = 18) and slow responders (n = 10) if they were smear-negative at 3, 5 or 8 weeks of treatment. alpha 1-acid gtycoprotein on enrolment and 1 week of treatment, alpha 1-antitrypsin at week 1 and C-reactive protein and C3 after 3 weeks of therapy were higher in slow responders than in fast responders. alpha 1-antitrypsin and alpha 1-acid glycoprotein may be helpful in predicting treatment response at the time of initiation of therapy, and could be used as early markers to identify patients with an increased likelihood of treatment failure. (C) 2008 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.

Item Type:	Article
Additional Information:	Doria Almeida, Maria Luiza Barbieri, Marco Antonio Gurgel, Ricardo Q. Abdurrahman, Saddiq Tsimiri Baba, Uthman Alhaji Hart, C. Anthony Shenkin, Alan Silva, Angela Maria de Souza, Luiz Cuevas, Luis Eduardo
Uncontrolled Keywords:	Tuberculosis; α1-acid glycoprotein; α1-antitrypsin; C-reactive protein; Treatment response; Brazil
Subjects:	WB Practice of Medicine > Medical Climatology > WB 710 Diseases of geographic areas WF Respiratory System > Tuberculosis > WF 200 Tuberculosis (General) WF Respiratory System > Tuberculosis > WF 205 Epidemiology WC Communicable Diseases > WC 20 Research (General) WF Respiratory System > Tuberculosis > WF 310 Therapy
Digital Object Identifer (DOI):	https://doi.org/10.1016/j.trstmh.2008.11.024
Depositing User:	Pauline Anderson
Date Deposited:	10 Mar 2010 14:26
Last Modified:	24 Jan 2022 15:08
URI:	https://archive.lstmed.ac.uk/id/eprint/216

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