Antibodies to variant surface antigens of Plasmodium falciparum - Infected erythrocytes and adhesion inhibitory antibodies are associated with placental malaria and have overlapping and distinct targets

Beeson, J. G., Mann, E. J., Elliott, S. R., Lema, V. M., Tadesse, E., Molyneux, Malcolm E, Brown, G. V. and Rogerson, S. J. (2004) 'Antibodies to variant surface antigens of Plasmodium falciparum - Infected erythrocytes and adhesion inhibitory antibodies are associated with placental malaria and have overlapping and distinct targets'. Journal of Infectious Disease, Vol 189, Issue 3, pp. 540-551.

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Abstract

We measured antibodies to chondroitin sulfate A (CSA)-binding and placental Plasmodium falciparum - infected red blood cells (PRBCs) among pregnant women with or without placental malaria. Immunoglobulin G to PRBC surface antigens was rare in uninfected primigravidae ( 3.7%), more prevalent in infected primigravidae (70%; P < .001), and common in infected (77%) and uninfected (83%) multigravidae. Similar patterns were seen for agglutinating antibodies, and antibodies were similar among women with past or active placental infection. PRBC adhesion to CSA was inhibited 60% by cells obtained from infected primigravidae but 24% by cells obtained from uninfected primigravidae (P = .025), whereas infection did not alter adhesion inhibition by multigravidae (77% inhibition). There was substantial heterogeneity in antibody type and levels. Antibodies did not correlate with parasite density or pregnancy outcome. Comparisons between antibodies suggest that adhesion-inhibitory antibodies and those to PRBC variant antigens have distinct and overlapping epitopes, may be acquired independently, and have different roles in immunity.

Item Type:	Article
Subjects:	QW Microbiology and Immunology > Antigens and Antibodies. Toxins and Antitoxins > QW 575 Antibodies QX Parasitology > Protozoa > QX 135 Plasmodia WQ Obstetrics > Pregnancy Complications > WQ 240 Pregnancy complications (General)
Digital Object Identifer (DOI):	https://doi.org/10.1086/381186
Depositing User:	Martin Chapman
Date Deposited:	19 Apr 2012 10:04
Last Modified:	17 Aug 2022 08:56
URI:	https://archive.lstmed.ac.uk/id/eprint/2178

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