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Kadia, Benjamin, Ramsteijn, Anouschka S., Dasi, Teena, Fahmida, Umi, Kulkarni, Bharati, Faye, Babacar, Htet, Min Kyaw, Sow, Doudou, Kalashikam, Rajender Rao, Sharma, Ritu, Sudibya, Arienta R.P., Kusuma, Sari, Angelin, Tiffany C., Nurfadilah, Mifa, Jobarteh, Modou L., Diop, Ndeye Sokhna, Gabain, Isobel, Calvo-Urbano, Beatriz, Ferguson, Elaine, Haggarty, Paul, Heffernan, Claire, Webster, Joanne P., Walker, Alan W. and Allen, Stephen 
ORCID: https://orcid.org/0000-0001-6675-249X
(2024)
'Assessment of the role of gut health in childhood stunting in a multi-site, longitudinal study in India, Indonesia, and Senegal: a UKRI GCRF Action Against Stunting Hub protocol'. BMJ Paediatrics Open, Vol 8, e001637.
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Abstract
Introduction: Childhood stunting has a complex aetiology, with poor gut health being an important contributor. This study will assess inter-relationships between maternal and infant gut health indices and infant linear growth. Inter-relationships between gut health indices, systemic inflammation, and growth hormones in early childhood will also be assessed.
Methods and analysis: A longitudinal observational study of cohorts of 600 newborns and their mothers in India, Indonesia, and Senegal will be conducted. Women will be recruited during pregnancy and their children followed up to age 24 months. Stool, urine, and blood samples will be collected from the women and children for assessments of helminthic and protozoal parasites, bacterial pathogens, faecal microbiota taxa, biomarkers of environmental enteric dysfunction, systemic inflammation, and growth hormones. Child anthropometric measurements will be collected at birth and at ages 3, 6, 9, 12, 18 and 24 months. The gut health indices will be integrated with cohort data from other Action Against Stunting Hub (AASH) workstreams for interdisciplinary analyses of childhood stunting and the development of a new typology of stunting.
Discussion: This study will advance scientific understanding of the role of gut health in childhood stunting and will contribute to a broader knowledge of the complex aetiology of this condition as part of the interdisciplinary AASH research to reduce the global burden of childhood stunting.
Ethics and dissemination: This study has been approved by the relevant Ethics Committees in Senegal, India, and Indonesia and LSHTM. The results will be submitted for publication in peer-reviewed journals.
| Item Type: | Article |
|---|---|
| Subjects: | WS Pediatrics > Child Care. Nutrition. Physical Examination > WS 115 Nutritional requirements. Nutrition disorders WS Pediatrics > WS 20 Research (General) WS Pediatrics > Diseases of Children and Adolescents > By System > WS 310 Digestive system |
| Faculty: Department: | Clinical Sciences & International Health > Clinical Sciences Department |
| Digital Object Identifer (DOI): | https://doi.org/10.1136/bmjpo-2022-001637 |
| Depositing User: | Cathy Waldron |
| Date Deposited: | 28 Feb 2024 14:07 |
| Last Modified: | 28 Feb 2024 14:54 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/21791 |
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