Why does HIV infection not lead to disseminated strongyloidiasis?

Viney, M. E., Brown, M., Omoding, N. E., Bailey, Wendi, Gardner, M. P., Roberts, E., Morgan, D., Elliott, A. M. and Whitworth, J. A. G. (2004) 'Why does HIV infection not lead to disseminated strongyloidiasis?'. Journal of Infectious Disease, Vol 190, Issue 12, pp. 2175-2180.

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Abstract

We investigated the hypothesis that host immunosuppression due to advancing human immunodeficiency virus (HIV) disease favors the direct development of infective larvae of Strongyloides stercoralis, which may facilitate hyperinfection and, hence, disseminated strongyloidiasis. To do this, we sought correlations between the immune status of the subjects and the development of S. stercoralis infections. Among 35 adults, there were significant negative rank correlations between CD4(+) cell counts and the proportions of free-living male and female worms. Thus, in individuals with preserved immune function, direct development of S. stercoralis is favored, whereas, in individuals with lesser immune function, indirect development is relatively more common. These results may explain the notable absence of disseminated strongyloidiasis in advanced HIV disease. Because disseminated infection requires the direct development of infective larvae in the gut, the observed favoring of indirect development in individuals immunosuppressed by advancing HIV disease is not consistent with the promotion of disseminated infection.

Item Type:	Article
Subjects:	WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503.5 Complications WC Communicable Diseases > Tropical and Parasitic Diseases > WC 865 Strongyloidiasis
Digital Object Identifer (DOI):	https://doi.org/10.1086/425935
Depositing User:	Ms Julia Martin
Date Deposited:	29 Nov 2011 14:10
Last Modified:	07 Dec 2018 09:44
URI:	https://archive.lstmed.ac.uk/id/eprint/2181

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