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Elliott, A. M., Hodsdon, W. S., Kyosiimire, J., Quigley, M. A., Nakiyingi, J. S., Namujju, P. B., Watera, C., French, Neil, Gilks, C.F., Dockrell, H. M. and Whitworth, J. A. G. (2004) 'Cytokine responses and progression to active tuberculosis in HIV-1-infected Ugandans: a prospective study'. Transactions of the Royal Society of Tropical Medicine and Hygiene, Vol 98, Issue 11, pp. 660-670.
Full text not available from this repository.Abstract
Identifying correlates of immunity or susceptibility to disease promotes understanding of pathogenesis and development of diagnostic tools, treatments, and vaccines. There is evidence that type 1 cytokine responses are associated with protection against tuberculosis, and suppression of type 1, or switching to type 2 responses, with susceptibility, but this has not been studied prospectively. We studied a cohort of 631 HIV-1-infected Ugandan adults. At enrolment we performed whole blood cultures for type 1 (interferon [IFN]-gamma, interleukin [IL]-2) and type 2/immunosuppressive (IL-5, IL-10) responses to mycobacterial antigens (purified protein derivative [PPD] and culture filtrate proteins [CFP]). The incidence of tuberculosis was not associated with IFN-gamma responses, but was higher among participants with IL-2 responses (adjusted rate ratios [RR]: PPD 3.48; CFP 3.99; P < 0.001). For tuberculin skin test-positive participants, high incidence was also associated with an IL-10 response to PPD (adjusted RR 6.24, P = 0.03); for those with a BCG scar, high incidence was associated with positive IL-5 responses (adjusted RRs: PPD 3.64, P = 0.006; CFP 3.44, P = 0.04). The association with IL-2 production may reflect a response to tuberculous infection or to activating disease; the associations with IL-10 and IL-5 are in keeping with the expected rote of immunosuppressive or type 2 cytokines. (C) 2004 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | tuberculosis hiv cytokines uganda mycobacterium-tuberculosis interferon-gamma t-cells infectious-diseases gene activation blood th1 immunity antigen adults |
| Subjects: | WA Public Health > WA 30 Socioeconomic factors in public health (General) WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503 Acquired immunodeficiency syndrome. HIV infections WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503.5 Complications WF Respiratory System > Tuberculosis > WF 200 Tuberculosis (General) |
| Digital Object Identifer (DOI): | https://doi.org/10.1016/j.trstmh.2004.01.007 |
| Depositing User: | Sarah Lewis-Newton |
| Date Deposited: | 21 Nov 2012 11:05 |
| Last Modified: | 21 Nov 2019 15:19 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/2229 |
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