Comparison of two combined vaccines against typhoid fever and hepatitis A in healthy adults

Beeching, Nicholas ORCID: https://orcid.org/0000-0002-7019-8791, Clarke, P. D., Kitchin, N. R. E., Pirmohamed, J., Veitch, K. and Weber, F. (2004) 'Comparison of two combined vaccines against typhoid fever and hepatitis A in healthy adults'. Vaccine, Vol 23, Issue 1, pp. 29-35.

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Abstract

A prospective, randomised, observer-blind, comparative study was performed in healthy adults with a new hepatitis A/typhoid combined vaccine. Viatim(TM), and the marketed Hepatyrix(TM) vaccine. Both vaccines induced high levels of protective antibodies, but typhoid responses were higher and hepatitis A responses more rapid with Viatim(TM) compared with Hepatyrix(TM). Both vaccines were well tolerated, no serious adverse events (SAEs) occurred, but more Viatim(TM) vaccinees had more mild or moderate local reactions (82.7%) than Hepatyrix(TM) (53.1%, p < 0.001). In this direct comparison Viatim(TM) induced more local reactions, but elicited a more rapid and higher immune response to both antigens than Hepatyrix(TM). (C) 2004 Elsevier Ltd. All rights reserved.

Item Type:	Article
Uncontrolled Keywords:	hepatitis a typhoid combined vaccine vi-capsular polysaccharide immunogenicity safety immunization vaccination travelers need
Subjects:	QV Pharmacology > QV 38 Drug action. QV Pharmacology > Drug Standardization. Pharmacognosy. Medicinal Plants > QV 771 Standardization and evaluation of drugs QW Microbiology and Immunology > Immunotherapy and Hypersensitivity > QW 805 Vaccines. Antitoxins. Toxoids WC Communicable Diseases > Infection. Bacterial Infections > Enteric Infections > WC 270 Typhoid fever WC Communicable Diseases > Virus Diseases > Viral Hemorrhagic Fevers. Other Virus Diseases > WC 536 Human viral hepatitis
Faculty: Department:	Groups (2002 - 2012) > Clinical Group
Digital Object Identifer (DOI):	https://doi.org/10.1016/j.vaccine.2004.05.040
Depositing User:	Sarah Lewis-Newton
Date Deposited:	26 Jan 2012 17:22
Last Modified:	09 Sep 2019 06:26
URI:	https://archive.lstmed.ac.uk/id/eprint/2254

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