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Liu, Danmeng, Cheng, Yue, Qu, Pengfei, Zhao, Doudou, Li, Shanshan, Zeng, Lingxia, Zhu, Zhonghai, Qi, Qi, Mi, Baibing, Zhang, Binyan, Jing, Hui, Yan, Hong, Wang, Duolao 
ORCID: https://orcid.org/0000-0003-2788-2464 and Dang, Shaonong
(2023)
'The interactions between maternal iron supplementation and iron metabolism-related genetic polymorphisms on birth outcomes: a prospective study in Chinese'. The Journal of Nutrition, Vol 153, Issue 8, pp. 2442-2452.
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The interactions between maternal iron supplementation and iron metabolism-related genetic polymorphisms on birth outcomes.pdf - Accepted Version Available under License Creative Commons Attribution Non-commercial No Derivatives. Download (974kB) | Preview |
Abstract
BACKGROUND
The effect of iron supplementation during pregnancy on birth outcomes may vary with maternal genetic background and needs more investigation.
OBJECTIVE
This prospective study aimed to evaluate the interactions between maternal iron supplementation and iron metabolism-related genetic polymorphisms on birth outcomes.
METHODS
This was a sub-study from a cluster-randomized control trial conducted in Northwest China, which included 860 women from the two micronutrient supplementation groups (folic acid (FA) and FA + iron group). Maternal peripheral blood, socio-demographic and health-related information, and neonatal birth outcomes were collected. Six single nucleotide polymorphisms (SNPs) in iron metabolism-related genes were genotyped. The alleles associated with decreased iron/hemoglobin status were used as the effect alleles. The genetic risk score (GRS) that reflected the genetic risk of low iron/hemoglobin status was estimated using the unweighted and weighted methods. Generalized estimating equation with small-sample corrections were applied to evaluate the interactions between iron supplementation and SNPs/GRS on birth outcomes.
RESULTS
There were significant interactions between maternal iron supplementation and rs7385804 (P=0.009), rs149411 (P=0.035), rs4820268 (P=0.031), the unweighted GRS (P=0.018), and the weighted GRS (P=0.009) on birth weight. Compared with FA supplementation only, FA + iron supplementation significantly increased birth weight among women with more effect alleles in rs7385804 (β: 88.8 g, 95% CI: 9.2, 168.3) and the GRSs (the highest unweighted GRS: β 135.5 g, 95% CI: 7.7, 263.4; the highest weighted GRS: β 145.9 g, 95% CI: 43.4, 248.5); it had a trend of decreasing birth weight and increasing low birth weight risk among women with fewer effect alleles. results CONCLUSION: In our population, maternal genetic background related to iron metabolism plays a significant role in determining the efficacy of iron supplementation. Routine iron supplementation could be more beneficial to fetal weight growth among mothers with higher genetic risk for low iron/hemoglobin status.
| Item Type: | Article |
|---|---|
| Subjects: | QV Pharmacology > Hematologic Agents > QV 183 Iron. Iron compounds WS Pediatrics > By Age Groups > WS 420 Newborn infants. Neonatology |
| Faculty: Department: | Clinical Sciences & International Health > Clinical Sciences Department |
| Digital Object Identifer (DOI): | https://doi.org/10.1016/j.tjnut.2023.06.036 |
| Depositing User: | Amy Carroll |
| Date Deposited: | 10 Jul 2023 09:21 |
| Last Modified: | 28 Jun 2024 03:13 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/22773 |
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