Immune system development during early childhood in tropical Latin America: evidence for the age-dependent down regulation of the innate immune response.

Teran, Rommy, Mitre, Edward, Vaca, Maritza, Erazo, Silvia, Oviedo, Gisela, Hübner, Marc P, Chico, Martha E, Mattapallil, Joseph J, Bickle, Quentin, Rodrigues, Laura C and Cooper, Philip (2011) 'Immune system development during early childhood in tropical Latin America: evidence for the age-dependent down regulation of the innate immune response.'. Clinical Immunology, Vol 138, Issue 3, pp. 299-310.

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Abstract

The immune response that develops in early childhood underlies the development of inflammatory diseases such as asthma and there are few data from tropical Latin America (LA). This study investigated the effects of age on the development of immunity during the first 5 years of life by comparing innate and adaptive immune responses in Ecuadorian children aged 6-9 months, 22-26 months, and 48-60 months. Percentages of naïve CD4+ T cells declined with age while those of memory CD4(+) and CD8(+) T cells increased indicating active development of the immune system throughout the first five years. Young infants had greater innate immune responses to TLR agonists compared to older children while regulatory responses including SEB-induced IL-10 and percentages of FoxP3(+) T-regulatory cells decreased with age. Enhanced innate immunity in early life may be important for host defense against pathogens but may increase the risk of immunopathology.

Item Type:	Article
Uncontrolled Keywords:	Innate immunity Adaptive immunity Childhood Tropics
Subjects:	QW Microbiology and Immunology > Immunity by Type > QW 541 Natural immunity. Immunogenetics QW Microbiology and Immunology > Immunity by Type > QW 551 Acquired immunity. Artificial immunity WB Practice of Medicine > Medical Climatology > WB 710 Diseases of geographic areas WS Pediatrics > Diseases of Children and Adolescents > General Diseases > WS 200 General works
Faculty: Department:	Groups (2002 - 2012) > Molecular & Biochemical Parasitology Group
Digital Object Identifer (DOI):	https://doi.org/10.1016/j.clim.2010.12.011
Depositing User:	Mary Creegan
Date Deposited:	07 Oct 2011 13:33
Last Modified:	06 Feb 2018 13:04
URI:	https://archive.lstmed.ac.uk/id/eprint/2341

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