The impact of probiotics and vitamin C on the prevention of upper respiratory tract symptoms in two preschool children cohorts

Paduchová, Zuzana, Nagyová, Zuzana, Wang, Duolao ORCID: https://orcid.org/0000-0003-2788-2464 and Muchová, Jana (2023) 'The impact of probiotics and vitamin C on the prevention of upper respiratory tract symptoms in two preschool children cohorts'. Nutrition Research and Practice, Vol 18, Issue 1, p. 98.

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Abstract

BACKGROUND/OBJECTIVES
The efficacy of Lab4 probiotic and vitamin C combination on the prevention of upper respiratory tract infections (URTIs) was investigated in two studies with children. Our objective was to pool dataset of 57 preschool children from the PROCHILD study (ISRCTN28722693) and the dataset of 50 preschool matched cohort from the PROCHILD-2 study (ISRCTN26587549) to evaluate the impact of probiotic/vitamin C combination on the prevention of upper respiratory tract symptoms and provide a more robust assessment of effect using detailed individual level data.

SUBJECTS/METHODS
The children were supplemented daily for 6 months with either the multistrain probiotic (1.25×1010 cfu/tablet consisting of two strains of Lactobacillus acidophilus CUL21 and CUL60, Bifidobacterium bifidum CUL20 and Bifidobacterium animalis subsp. lactis CUL34) plus 50 mg vitamin C or a placebo.

RESULTS
In the pooled analysis of the individual participant data (per protocol population), significant reductions were observed for the incidence (−25%; 95% confidence interval [CI], 0.66, 0.85; P < 0.0001) and duration (−14.9 days; 95% CI, −24.8, −5.1; P = 0.0030) of typical URTI symptoms in the active group compared with the placebo. The incidence rates of absenteeism from preschool (IR ratio, 0.75; 95% CI, 0.66, 0.86; P < 0.0001), paediatric visits (IR ratio, 0.56; 95% CI, 0.47; 0.68; P < 0.0001) and antibiotic usage (IR ratio, 0.53; 95% CI, 0.39, 0.71; P < 0.0001) were also significantly reduced.

CONCLUSION
The pooled analysis findings of comparable preschool cohorts from two studies indicate that the supplementation with probiotic and vitamin C combination is beneficial in the prevention and management of URTI symptoms.

Item Type:	Article
Subjects:	QU Biochemistry > Vitamins > QU 160 Vitamins. Vitamin requirements WC Communicable Diseases > Virus Diseases > Viral Respiratory Tract Infections. Respirovirus Infections > WC 505 Viral respiratory tract infections WS Pediatrics > Diseases of Children and Adolescents > By System > WS 280 Respiratory system WS Pediatrics > By Age Groups > WS 440 Preschool child
Faculty: Department:	Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI):	https://doi.org/10.4162/nrp.2024.18.1.98
SWORD Depositor:	JISC Pubrouter
Depositing User:	JISC Pubrouter
Date Deposited:	15 Feb 2024 13:25
Last Modified:	15 Feb 2024 13:25
URI:	https://archive.lstmed.ac.uk/id/eprint/24030

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