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Omore, Richard, Awuor, Alex O, Ogwel, Billy, Okonji, Caleb, Sonye, Catherine, Oreso, Caren, Akelo, Victor, Amollo, Manase, Ogudi, Isaiah, Anyango, Raphael O, Audi, Marjorie, Apondi, Evans, Riziki, Laura, Ambila, Lilian, Dilruba, Nasrin, Muok, Erick, Munga, Stephen, Ochieng, John B and Kotloff, Karen L (2024) 'The Enterics for Global Health (EFGH) Shigella Surveillance Study in Kenya'. Open Forum Infectious Diseases, Vol 11, Issue Supplement_1, S91-S100.
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Abstract
Background: Although Shigella is an important cause of diarrhea in Kenyan children, robust research platforms capable of conducting incidence-based Shigella estimates and eventual Shigella-targeted clinical trials are needed to improve Shigella-related outcomes in children. Here, we describe characteristics of a disease surveillance platform whose goal is to support incidence and consequences of Shigella diarrhea as part of multicounty surveillance aimed at preparing sites and assembling expertise for future Shigella vaccine trials.
Methods: We mobilized our preexisting expertise in shigellosis, vaccinology, and diarrheal disease epidemiology, which we combined with our experience conducting population-based sampling, clinical trials with high (97%–98%) retention rates, and healthcare utilization surveys. We leveraged our established demographic surveillance system (DSS), our network of healthcare centers serving the DSS, and our laboratory facilities with staff experienced in performing microbiologic and molecular diagnostics to identify enteric infections. We joined these resources with an international network of sites with similar capabilities and infrastructure to form a cohesive scientific network, designated Enterics for Global Health (EFGH), with the aim of expanding and updating our knowledge of the epidemiology and adverse consequences of shigellosis and enriching local research and career development priorities.
Conclusions: Shigella surveillance data from this platform could help inform Shigella vaccine trials.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NOT_LSTM |
| Subjects: | WA Public Health > WA 30 Socioeconomic factors in public health (General) WA Public Health > Health Administration and Organization > WA 530 International health administration WS Pediatrics > Diseases of Children and Adolescents > By System > WS 312 Diarrheal disorders |
| Faculty: Department: | Clinical Sciences & International Health > Clinical Sciences Department |
| Digital Object Identifer (DOI): | https://doi.org/10.1093/ofid/ofad654 |
| SWORD Depositor: | JISC Pubrouter |
| Depositing User: | JISC Pubrouter |
| Date Deposited: | 28 Mar 2024 13:46 |
| Last Modified: | 01 Nov 2024 09:55 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/24264 |
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